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Implicating genes, ...
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
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- Kanoni, Stavroula (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England,Queen Mary University
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Graham, Sarah E (author)
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Wang, Yuxuan (author)
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Surakka, Ida (author)
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Ramdas, Shweta (author)
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Zhu, Xiang (author)
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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Bhatti, Konain Fatima (author)
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Vedantam, Sailaja (author)
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Winkler, Thomas W (author)
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Locke, Adam E (author)
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Marouli, Eirini (author)
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Zajac, Greg J M (author)
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Wu, Kuan-Han H (author)
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Ntalla, Ioanna (author)
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Hui, Qin (author)
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Klarin, Derek (author)
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Hilliard, Austin T (author)
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Wang, Zeyuan (author)
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Xue, Chao (author)
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Thorleifsson, Gudmar (author)
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Helgadottir, Anna (author)
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Gudbjartsson, Daniel F (author)
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Holm, Hilma (author)
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Olafsson, Isleifur (author)
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Hwang, Mi Yeong (author)
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Han, Sohee (author)
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Akiyama, Masato (author)
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Sakaue, Saori (author)
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Terao, Chikashi (author)
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Kanai, Masahiro (author)
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Zhou, Wei (author)
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Brumpton, Ben M (author)
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Rasheed, Humaira (author)
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Havulinna, Aki S (author)
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Veturi, Yogasudha (author)
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Pacheco, Jennifer Allen (author)
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Rosenthal, Elisabeth A (author)
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Lingren, Todd (author)
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Feng, QiPing (author)
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Kullo, Iftikhar J (author)
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Narita, Akira (author)
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Takayama, Jun (author)
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Martin, Hilary C (author)
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Hunt, Karen A (author)
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Trivedi, Bhavi (author)
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Haessler, Jeffrey (author)
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Giulianini, Franco (author)
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Bradford, Yuki (author)
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Miller, Jason E (author)
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Campbell, Archie (author)
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Lin, Kuang (author)
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Millwood, Iona Y (author)
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Rasheed, Asif (author)
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Hindy, George (author)
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Faul, Jessica D (author)
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Zhao, Wei (author)
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Weir, David R (author)
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Turman, Constance (author)
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Huang, Hongyan (author)
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- Graff, Mariaelisa (author)
- Boston University
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Choudhury, Ananyo (author)
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Sengupta, Dhriti (author)
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Mahajan, Anubha (author)
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Brown, Michael R (author)
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Zhang, Weihua (author)
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Yu, Ketian (author)
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Schmidt, Ellen M (author)
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Pandit, Anita (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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Yin, Xianyong (author)
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Luan, Jian'an (author)
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Zhao, Jing-Hua (author)
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Matsuda, Fumihiko (author)
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Jang, Hye-Mi (author)
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Yoon, Kyungheon (author)
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Medina-Gomez, Carolina (author)
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Pitsillides, Achilleas (author)
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Hottenga, Jouke Jan (author)
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Wood, Andrew R (author)
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Ji, Yingji (author)
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Gao, Zishan (author)
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Haworth, Simon (author)
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Yousri, Noha A (author)
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Mitchell, Ruth E (author)
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Chai, Jin Fang (author)
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Aadahl, Mette (author)
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Bjerregaard, Anne A (author)
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Yao, Jie (author)
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Manichaikul, Ani (author)
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Hwu, Chii-Min (author)
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Hung, Yi-Jen (author)
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Warren, Helen R (author)
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Ramirez, Julia (author)
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Bork-Jensen, Jette (author)
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Kårhus, Line L (author)
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Goel, Anuj (author)
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- Sabater-Lleal, Maria (author)
- Karolinska Institutet
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Noordam, Raymond (author)
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Mauro, Pala (author)
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Matteo, Floris (author)
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McDaid, Aaron F (author)
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Marques-Vidal, Pedro (author)
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Wielscher, Matthias (author)
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Trompet, Stella (author)
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Sattar, Naveed (author)
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Møllehave, Line T (author)
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Munz, Matthias (author)
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Zeng, Lingyao (author)
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Huang, Jianfeng (author)
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Yang, Bin (author)
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- Poveda, A. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Kurbasic, A. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Lamina, Claudia (author)
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Forer, Lukas (author)
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Scholz, Markus (author)
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Galesloot, Tessel E (author)
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Bradfield, Jonathan P (author)
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Ruotsalainen, Sanni E (author)
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Daw, EWarwick (author)
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Zmuda, Joseph M (author)
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Mitchell, Jonathan S (author)
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Fuchsberger, Christian (author)
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Christensen, Henry (author)
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Brody, Jennifer A (author)
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Vazquez-Moreno, Miguel (author)
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Feitosa, Mary F (author)
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Wojczynski, Mary K (author)
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Wang, Zhe (author)
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Preuss, Michael H (author)
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Mangino, Massimo (author)
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Christofidou, Paraskevi (author)
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Verweij, Niek (author)
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Benjamins, Jan W (author)
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Engmann, Jorgen (author)
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Tsao, Noah L (author)
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Verma, Anurag (author)
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Slieker, Roderick C (author)
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Lo, Ken Sin (author)
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Zilhao, Nuno R (author)
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Le, Phuong (author)
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Kleber, Marcus E (author)
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Delgado, Graciela E (author)
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Huo, Shaofeng (author)
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Ikeda, Daisuke D (author)
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Iha, Hiroyuki (author)
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Yang, Jian (author)
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Liu, Jun (author)
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- Demirkan, Ayşe (author)
- Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands;Univ Surrey, Dept Clin & Expt Res, Sect Stat Multiom, Guildford, Surrey, England
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Leonard, Hampton L (author)
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Marten, Jonathan (author)
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Frank, Mirjam (author)
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Schmidt, Börge (author)
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Smyth, Laura J (author)
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Cañadas-Garre, Marisa (author)
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Wang, Chaolong (author)
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Nakatochi, Masahiro (author)
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Wong, Andrew (author)
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Hutri-Kähönen, Nina (author)
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Sim, Xueling (author)
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Xia, Rui (author)
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Huerta-Chagoya, Alicia (author)
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Fernandez-Lopez, Juan Carlos (author)
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- Lyssenko, V. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Nongmaithem, Suraj S (author)
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Bayyana, Swati (author)
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Stringham, Heather M (author)
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Irvin, Marguerite R (author)
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Oldmeadow, Christopher (author)
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Kim, Han-Na (author)
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Ryu, Seungho (author)
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Timmers, Paul R H J (author)
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Arbeeva, Liubov (author)
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Dorajoo, Rajkumar (author)
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Lange, Leslie A (author)
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Prasad, Gauri (author)
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Lorés-Motta, Laura (author)
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Pauper, Marc (author)
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Long, Jirong (author)
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Li, Xiaohui (author)
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Theusch, Elizabeth (author)
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Takeuchi, Fumihiko (author)
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Spracklen, Cassandra N (author)
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Loukola, Anu (author)
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Bollepalli, Sailalitha (author)
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Warner, Sophie C (author)
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Wang, Ya Xing (author)
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Wei, Wen B (author)
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Nutile, Teresa (author)
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Ruggiero, Daniela (author)
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Sung, Yun Ju (author)
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Chen, Shufeng (author)
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Liu, Fangchao (author)
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Yang, Jingyun (author)
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Kentistou, Katherine A (author)
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Banas, Bernhard (author)
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Nardone, Giuseppe Giovanni (author)
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Meidtner, Karina (author)
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Bielak, Lawrence F (author)
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Smith, Jennifer A (author)
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Hebbar, Prashantha (author)
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Farmaki, Aliki-Eleni (author)
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Hofer, Edith (author)
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Lin, Maoxuan (author)
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Concas, Maria Pina (author)
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Vaccargiu, Simona (author)
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van der Most, Peter J (author)
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Pitkänen, Niina (author)
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Cade, Brian E (author)
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van der Laan, Sander W (author)
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Chitrala, Kumaraswamy Naidu (author)
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Weiss, Stefan (author)
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Bentley, Amy R (author)
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Doumatey, Ayo P (author)
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Adeyemo, Adebowale A (author)
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Lee, Jong Young (author)
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Petersen, Eva R B (author)
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Nielsen, Aneta A (author)
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Choi, Hyeok Sun (author)
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- Nethander, Maria, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Core Facilities, Bioinformatics
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Freitag-Wolf, Sandra (author)
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Southam, Lorraine (author)
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Rayner, Nigel W (author)
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Wang, Carol A (author)
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Lin, Shih-Yi (author)
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Wang, Jun-Sing (author)
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Couture, Christian (author)
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Lyytikäinen, Leo-Pekka (author)
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Nikus, Kjell (author)
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Cuellar-Partida, Gabriel (author)
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Vestergaard, Henrik (author)
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Hidalgo, Bertha (author)
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Giannakopoulou, Olga (author)
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Cai, Qiuyin (author)
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Obura, Morgan O (author)
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van Setten, Jessica (author)
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Li, Xiaoyin (author)
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Liang, Jingjing (author)
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Tang, Hua (author)
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Terzikhan, Natalie (author)
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Shin, Jae Hun (author)
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Jackson, Rebecca D (author)
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Reiner, Alexander P (author)
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Martin, Lisa Warsinger (author)
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Chen, Zhengming (author)
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- Li, Liming (author)
- Karolinska Institutet
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Kawaguchi, Takahisa (author)
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Thiery, Joachim (author)
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Bis, Joshua C (author)
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Launer, Lenore J (author)
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Li, Huaixing (author)
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Nalls, Mike A (author)
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Raitakari, Olli T (author)
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Ichihara, Sahoko (author)
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Wild, Sarah H (author)
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Nelson, Christopher P (author)
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Campbell, Harry (author)
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Jäger, Susanne (author)
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Nabika, Toru (author)
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Al-Mulla, Fahd (author)
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Niinikoski, Harri (author)
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Braund, Peter S (author)
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Kolcic, Ivana (author)
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- Kovacs, Peter (author)
- Karolinska Institutet
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Giardoglou, Tota (author)
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Katsuya, Tomohiro (author)
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de Kleijn, Dominique (author)
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de Borst, Gert J (author)
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Kim, Eung Kweon (author)
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Adams, Hieab H H (author)
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Ikram, M Arfan (author)
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Zhu, Xiaofeng (author)
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Asselbergs, Folkert W (author)
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Kraaijeveld, Adriaan O (author)
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Beulens, Joline W J (author)
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Shu, Xiao-Ou (author)
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Rallidis, Loukianos S (author)
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Pedersen, Oluf (author)
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Hansen, Torben (author)
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Mitchell, Paul (author)
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Hewitt, Alex W (author)
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Kähönen, Mika (author)
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Pérusse, Louis (author)
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Bouchard, Claude (author)
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Tönjes, Anke (author)
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Chen, Yii-Der Ida (author)
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Pennell, Craig E (author)
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Mori, Trevor A (author)
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Lieb, Wolfgang (author)
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Franke, Andre (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Cho, Yoon Shin (author)
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Lee, Hyejin (author)
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Yuan, Jian-Min (author)
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Koh, Woon-Puay (author)
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Rhee, Sang Youl (author)
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Woo, Jeong-Taek (author)
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Heid, Iris M (author)
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Stark, Klaus J (author)
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Zimmermann, Martina E (author)
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Völzke, Henry (author)
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Homuth, Georg (author)
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Evans, Michele K (author)
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Zonderman, Alan B (author)
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Polasek, Ozren (author)
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Pasterkamp, Gerard (author)
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Hoefer, Imo E (author)
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Redline, Susan (author)
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Pahkala, Katja (author)
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Oldehinkel, Albertine J (author)
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Snieder, Harold (author)
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Biino, Ginevra (author)
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Schmidt, Reinhold (author)
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Schmidt, Helena (author)
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Bandinelli, Stefania (author)
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Dedoussis, George (author)
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Thanaraj, Thangavel Alphonse (author)
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Kardia, Sharon L R (author)
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Peyser, Patricia A (author)
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Kato, Norihiro (author)
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Schulze, Matthias B (author)
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Girotto, Giorgia (author)
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Böger, Carsten A (author)
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Jung, Bettina (author)
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Joshi, Peter K (author)
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Bennett, David A (author)
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De Jager, Philip L (author)
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Lu, Xiangfeng (author)
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Mamakou, Vasiliki (author)
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Brown, Morris (author)
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Caulfield, Mark J (author)
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Munroe, Patricia B (author)
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Guo, Xiuqing (author)
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Ciullo, Marina (author)
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Jonas, Jost B (author)
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Samani, Nilesh J (author)
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Kaprio, Jaakko (author)
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- Franks, P.W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Tusié-Luna, Teresa (author)
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Aguilar-Salinas, Carlos A (author)
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Adair, Linda S (author)
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Bechayda, Sonny Augustin (author)
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de Silva, H Janaka (author)
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Wickremasinghe, Ananda R (author)
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Krauss, Ronald M (author)
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Wu, Jer-Yuarn (author)
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Zheng, Wei (author)
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Hollander, Anneke Iden (author)
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Bharadwaj, Dwaipayan (author)
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Correa, Adolfo (author)
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Wilson, James G (author)
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Lind, Lars (author)
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Heng, Chew-Kiat (author)
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Nelson, Amanda E (author)
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Golightly, Yvonne M (author)
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Wilson, James F (author)
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Penninx, Brenda (author)
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Kim, Hyung-Lae (author)
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Attia, John (author)
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Scott, Rodney J (author)
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Rao, D C (author)
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Arnett, Donna K (author)
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Hunt, Steven C (author)
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Walker, Mark (author)
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Koistinen, Heikki A (author)
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Chandak, Giriraj R (author)
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Mercader, Josep M (author)
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Costanzo, Maria C (author)
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Jang, Dongkeun (author)
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Burtt, Noël P (author)
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Villalpando, Clicerio Gonzalez (author)
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Orozco, Lorena (author)
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Fornage, Myriam (author)
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Tai, EShyong (author)
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van Dam, Rob M (author)
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Lehtimäki, Terho (author)
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Chaturvedi, Nish (author)
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Yokota, Mitsuhiro (author)
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Liu, Jianjun (author)
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Reilly, Dermot F (author)
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McKnight, Amy Jayne (author)
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Kee, Frank (author)
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Jöckel, Karl-Heinz (author)
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McCarthy, Mark I (author)
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Palmer, Colin N A (author)
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Vitart, Veronique (author)
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Hayward, Caroline (author)
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Simonsick, Eleanor (author)
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van Duijn, Cornelia M (author)
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Jin, Zi-Bing (author)
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Qu, Jia (author)
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Hishigaki, Haretsugu (author)
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Lin, Xu (author)
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März, Winfried (author)
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Gudnason, Vilmundur (author)
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Tardif, Jean-Claude (author)
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Lettre, Guillaume (author)
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Hart, Leen M 't (author)
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Elders, Petra J M (author)
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Damrauer, Scott M (author)
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Kumari, Meena (author)
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Kivimaki, Mika (author)
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van der Harst, Pim (author)
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Spector, Tim D (author)
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Loos, Ruth J F (author)
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Province, Michael A (author)
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Parra, Esteban J (author)
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Cruz, Miguel (author)
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Psaty, Bruce M (author)
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Brandslund, Ivan (author)
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Pramstaller, Peter P (author)
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Rotimi, Charles N (author)
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Christensen, Kaare (author)
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Ripatti, Samuli (author)
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Widén, Elisabeth (author)
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Hakonarson, Hakon (author)
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Grant, Struan F A (author)
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Kiemeney, Lambertus A L M (author)
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de Graaf, Jacqueline (author)
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Loeffler, Markus (author)
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Kronenberg, Florian (author)
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Gu, Dongfeng (author)
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Erdmann, Jeanette (author)
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Schunkert, Heribert (author)
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Franks, Paul W (author)
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Linneberg, Allan (author)
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Jukema, J Wouter (author)
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Khera, Amit V (author)
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Männikkö, Minna (author)
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Jarvelin, Marjo-Riitta (author)
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Kutalik, Zoltan (author)
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Francesco, Cucca (author)
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Mook-Kanamori, Dennis O (author)
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van Dijk, Ko Willems (author)
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Watkins, Hugh (author)
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Strachan, David P (author)
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Grarup, Niels (author)
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Sever, Peter (author)
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Poulter, Neil (author)
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Chuang, Lee-Ming (author)
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Rotter, Jerome I (author)
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Dantoft, Thomas M (author)
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Karpe, Fredrik (author)
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Neville, Matt J (author)
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Timpson, Nicholas J (author)
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Cheng, Ching-Yu (author)
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Wong, Tien-Yin (author)
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Khor, Chiea Chuen (author)
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Li, Hengtong (author)
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Sabanayagam, Charumathi (author)
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Peters, Annette (author)
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Gieger, Christian (author)
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Hattersley, Andrew T (author)
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Pedersen, Nancy L (author)
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Magnusson, Patrik K E (author)
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Boomsma, Dorret I (author)
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Willemsen, Allegonda H M (author)
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Cupples, LAdrienne (author)
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van Meurs, Joyce B J (author)
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Ghanbari, Mohsen (author)
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Gordon-Larsen, Penny (author)
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Huang, Wei (author)
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Kim, Young Jin (author)
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Tabara, Yasuharu (author)
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Wareham, Nicholas J (author)
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Langenberg, Claudia (author)
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Zeggini, Eleftheria (author)
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Kuusisto, Johanna (author)
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Laakso, Markku (author)
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA
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Abecasis, Goncalo (author)
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Chambers, John C (author)
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Kooner, Jaspal S (author)
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de Vries, Paul S (author)
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Morrison, Alanna C (author)
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Hazelhurst, Scott (author)
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Ramsay, Michèle (author)
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North, Kari E (author)
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Daviglus, Martha (author)
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Kraft, Peter (author)
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Martin, Nicholas G (author)
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Whitfield, John B (author)
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Abbas, Shahid (author)
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Saleheen, Danish (author)
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Walters, Robin G (author)
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Holmes, Michael V (author)
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Black, Corri (author)
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Smith, Blair H (author)
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Baras, Aris (author)
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Justice, Anne E (author)
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Buring, Julie E (author)
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Ridker, Paul M (author)
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Chasman, Daniel I (author)
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Kooperberg, Charles (author)
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Tamiya, Gen (author)
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Yamamoto, Masayuki (author)
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van Heel, David A (author)
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Trembath, Richard C (author)
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Wei, Wei-Qi (author)
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Jarvik, Gail P (author)
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Namjou, Bahram (author)
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Hayes, M Geoffrey (author)
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Ritchie, Marylyn D (author)
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Jousilahti, Pekka (author)
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Salomaa, Veikko (author)
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Hveem, Kristian (author)
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Åsvold, Bjørn Olav (author)
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Kubo, Michiaki (author)
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Kamatani, Yoichiro (author)
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Okada, Yukinori (author)
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Murakami, Yoshinori (author)
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Kim, Bong-Jo (author)
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Thorsteinsdottir, Unnur (author)
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Stefansson, Kari (author)
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Zhang, Jifeng (author)
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Chen, YEugene (author)
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Ho, Yuk-Lam (author)
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Lynch, Julie A (author)
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Rader, Daniel J (author)
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Tsao, Philip S (author)
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Chang, Kyong-Mi (author)
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Cho, Kelly (author)
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O'Donnell, Christopher J (author)
-
Gaziano, John M (author)
-
Wilson, Peter W F (author)
-
Frayling, Timothy M (author)
-
Hirschhorn, Joel N (author)
-
Kathiresan, Sekar (author)
-
Mohlke, Karen L (author)
-
Sun, Yan V (author)
-
Morris, Andrew P (author)
-
Boehnke, Michael (author)
-
Brown, Christopher D (author)
-
Natarajan, Pradeep (author)
-
Deloukas, Panos (author)
-
Willer, Cristen J (author)
-
Assimes, Themistocles L (author)
-
Peloso, Gina M (author)
-
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(creator_code:org_t)
-
et al
- 2022-12-27
- 2022
- English.
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In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Abstract
Subject headings
Close
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Humans
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Sex Characteristics
- Phenotype
- Lipids
- genetics
- Polymorphism
- Single Nucleotide
- Genetic Pleiotropy
- Cholesterol
- Cholesterol
- Genetics
- Genome-wide association study
- GWAS
- lipid
- genetic predisposition
- genome-wide association study
- human
- meta analysis
- phenotype
- pleiotropy
- sexual characteristics
- single nucleotide polymorphism
- Polymorphism, Single Nucleotide
Publication and Content Type
- ref (subject category)
- art (subject category)
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Genome biology
- By the university
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University of Gothenburg
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Karolinska Institutet
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Uppsala University
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Lund University