| 1. |
- Beyer, J., et al.
(författare)
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Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer
- 2013
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Ingår i: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 24:4, s. 878-888
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Forskningsöversikt (refereegranskat)abstract
- In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497-513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, similar to 50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.
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| 2. |
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| 3. |
- Waaijers, Susanne L., et al.
(författare)
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Persistence, Bioaccumulation, and Toxicity of Halogen-Free Flame Retardants
- 2013
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Ingår i: Reviews of Environmental Contamination and Toxicology. - New York, NY : Springer. - 9781461447160 - 9781461447177 ; , s. 1-71
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Bokkapitel (refereegranskat)abstract
- Polymers are synthetic organic materials having a high carbon and hydrogen content, which make them readily combustible. Polymers have many indoor uses and their flammability makes them a fire hazard. Therefore, flame retardants (FRs) are incorporated into these materials as a safety measure. Brominated flame retardants (BFRs), which accounted for about 21% of the total world market of FRs, have several unintended negative effects on the environment and human health. Hence, there is growing interest in finding appropriate alternative halogen-free flame retardants (HFFRs). Many of these HFFRs are marketed already, although their environ- mental behavior and toxicological properties are often only known to a limited extent, and their potential impact on the environment cannot yet be properly assessed. Therefore, we undertook this review to make an inventory of the available data that exists (up to September 2011) on the physical-chemical properties, pro- duction volumes, persistence, bioaccumulation, and toxicity (PBT) of a selection of HFFRs that are potential replacements for BFRs in polymers. Large data gaps were identified for the physical-chemical and the PBT properties of the reviewed HFFRs. Because these HFFRs are currently on the market, there is an urgent need to fill these data gaps. Enhanced transparency of methodology and data are needed to reevaluate certain test results that appear contradictory, and, if this does not provide new insights, further research should be performed. TPP has been studied quite extensively and it is clearly persistent, bioaccumulative, and toxic. So far, RDP and BDP have demonstrated low to high ecotoxicity and persistence. The compounds ATH and ZB exerted high toxicity to some species and ALPI appeared to be persistent and has low to moderate reported ecotoxicity. DOPO and MPP may be persistent, but this view is based merely on one or two studies, clearly indicating a lack of information. Many degradation studies have been performed on PER and show low persistence, with a few exceptions. Additionally, there is too l ittle information on the bioaccumulation potential of PER. APP mostly has low PBT properties; however, moderate ecotoxicity was reported in two studies. Mg(OH)₂, ZHS, and ZS do not show such remarkably high bioaccumulation or toxicity, but large data gaps exist for these compounds also. Nevertheless, we consider the latter compounds to be the most promising among alternative HFFRs. To assess whether the presently reviewed HFFRs are truly suitable alternatives, each compound should be examined individually by comparing its PBT values with those of the relevant halogenated flame retardant. Until more data are available, it remains impossible to accurately evaluate the risk of each of these compounds, including the ones that are already extensively marketed.
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| 4. |
- Brandsma, Sicco H., et al.
(författare)
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Two organophosphorus flame retardants, resorcinol bis (diphenylphosphate)(PBDPP) and bisphenol A bis (diphenylphosphate) (BPA-BDPP) used as alternatives for BDE209 detected in dust
- 2013
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 1086-931X .- 1520-6912 .- 0013-936X .- 1520-5851. ; 47:24, s. 14434-14441
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Tidskriftsartikel (refereegranskat)abstract
- Resorcinol bis(diphenylphosphate) (RBDPP) and bisphenol A bis(diphenylphosphate) (BPA-BDPP) are two halogen-free organophosphorus flame retardant (PFRs) that are used as an alternative for the decabromodiphenyl ether (Deca-BDE) technical mixture in TV/flatscreen housing and other electronic consumer products.' In this study, dust samples were collected from various microenvironments in The Netherlands (houses, cars), Greece.(houses), and Sweden (apartments, cars, furniture stores, electronics stores) and analyzed for RBDPP and BPA-BDPP. Additionally, the dust samples from The Netherlands were analyzed for decabromodiphenyl ether (BDE-209) for comparison and for TPHP, which is a byproduct in the RBDPP and BPA-BDPP technical products. BPA-BDPP was detected in almost all dust samples from The Netherlands, Greece, and Sweden. Highest concentrations were found in dust samples collected on electronic equipment from all three countries with BPA-BDPP levels ranging from <0.1 to 1300 mu g/g and RBDPP levels from <0.04 to 520 mu g/g. RBDPP and BPA-BDPP levels in dust collected further away from the electronics (source) were usually lower. BDE-209 levels in The Netherlands dust samples collected on and around the electronics were similar and much lower than the BPA-BDPP/RBDPP levels, indicating that the electronics were not the source of BDE-209. Strong positive correlations were found between TPHP concentrations and those of RBDPP (r = 0.805) and BPA-BDPP (r = 0.924), probably due to TPHP being a byproduct in commercial RBDPP and BPA-BDPP mixtures in electronics. To our knowledge, this is the first time that RBDPP and BPA-BDPP were detected in dust samples from Europe.
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| 5. |
- Rockström, Johan, et al.
(författare)
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A safe operating space for humanity
- 2013
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Ingår i: The Future of Nature. - : Yale University Press. - 9780300184617 ; , s. 491-501
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Bokkapitel (refereegranskat)
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| 6. |
- Sillars-Hardebol, Anke H., et al.
(författare)
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BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain
- 2012
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Ingår i: Journal of Pathology. - : Wiley. - 0022-3417 .- 1096-9896. ; 226:3, s. 442-450
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Tidskriftsartikel (refereegranskat)abstract
- Colorectal cancer (CRC) is the second leading cause of cancer death in the western world. The majority of CRCs, which develop from adenoma precursor lesions, show gain of chromosome arm 20q, where BCL2L1 is located. BCL2L1 is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-xL) and a pro-apoptotic (Bcl-xS) splice variant. The aim of the present study was to investigate whether BCL2L1 contributes to 20q gain-driven colorectal adenoma-to-carcinoma progression. To this end, the functional role of BCL2L1 in cancer-related processes was investigated, and differences in BCL2L1 DNA, mRNA, and protein levels were compared between colorectal adenomas and CRCs, as well as between tumours with and without 20q gain. Down-modulation of BCL2L1 inhibited cell viability and anchorage-independent growth of CRC cells, while invasion was not affected. BCL2L1 DNA copy number and protein expression were increased in CRCs compared to adenomas (p = 0.00005 and p = 0.03, respectively), while mRNA expression was not. Differences in BCL2L1 protein expression were even more pronounced between tumours with and without 20q gain (p = 0.0001). In conclusion, BCL2L1 is functionally involved in several cancer-related processes and its protein expression is associated with 20q gain. This supports a role for 20q gain-dependent expression of BCL2L1 in colorectal adenoma-to-carcinoma progression. However, the absence of a direct correlation between BCL2L1 mRNA and protein expression implies that BCL2L1 protein expression is regulated at the post-transcriptional level by a distinct factor on the 20q amplicon (eg ZNF217, AURKA or miRNAs). Therefore, even though BCL2L1 affects CRC biology in a 20q gain-dependent manner, it is not likely to be a driver of chromosome 20q gain associated adenoma-to-carcinoma progression.
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| 7. |
- Sillars-Hardebol, Anke H., et al.
(författare)
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CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression
- 2012
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Ingår i: Cellular Oncology. - : Springer Science and Business Media LLC. - 2211-3428 .- 2211-3436. ; 35:4, s. 293-300
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Tidskriftsartikel (refereegranskat)abstract
- Background Gain of chromosome 20q is an important factor in the progression from colorectal adenomas to carcinomas. Genes that drive 20q gain are expected to show correlation of mRNA and protein expression levels with 20q DNA copy number status while functionally influencing cancer processes. CSE1L, DIDO1 and RBM39 are located on the 20q amplicon and affect processes such as cell viability and anchorage-independent growth in colorectal cancer. This study aimed to investigate whether CSE1L, DIDO1 and RBM39 may drive 20q amplification.Methods Protein expression levels were examined by immunohistochemical evaluation of tissue microarrays containing a series of colorectal adenoma and carcinoma samples, which were characterized by genome-wide (microarray-based) DNA and mRNA profiling.Results CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. CSE1L protein expression was not associated with 20q gain, although its expression was increased in carcinomas compared to adenomas. DIDO1 and RBM39 protein expression was quite strong in the majority of tumors irrespective of 20q DNA copy number status.Conclusion The lack of correlation between protein expression levels and 20q DNA copy number status implies that CSE1L, DIDO1 and RBM39 are merely passengers rather than drivers of chromosome 20q gain in colorectal adenoma-to-carcinoma progression.
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| 8. |
- Sillars-Hardebol, Anke H, et al.
(författare)
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TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression
- 2012
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 61:11, s. 1568-1575
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Tidskriftsartikel (refereegranskat)abstract
- Background and objectiveProgression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q amplicon may drive carcinogenesis. The aim of this study was to identify genes located on the 20q amplicon that promote progression of colorectal adenoma to carcinoma.DesignFunctional assays were performed for 32 candidate driver genes for which a positive correlation between 20q DNA copy number and mRNA expression had been demonstrated. Effects of gene knockdown on cell viability, anchorage-independent growth, and invasion were analysed in colorectal cancer cell lines with 20q gain. Colorectal tumour protein expression was examined by immunohistochemical staining of tissue microarrays.ResultsTPX2, AURKA, CSE1L, DIDO1, HM13, TCFL5, SLC17A9, RBM39 and PRPF6 affected cell viability and/or anchorage-independent growth. Chromosome 20q DNA copy number status correlated significantly with TPX2 and AURKA protein levels in a series of colorectal adenomas and carcinomas. Moreover, downmodulation of TPX2 and AURKA was shown to inhibit invasion.ConclusionThese data identify TPX2 (20q11) and AURKA (20q13.2) as two genes located on distinct regions of chromosome 20q that promote 20q amplicon-driven progression of colorectal adenoma to carcinoma. Therefore the selection advantage imposed by 20q gain in tumour progression is achieved by gain-of-function of multiple cancer-related genes-knowledge that can be translated into novel tests for early diagnosis of progressive adenomas.
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| 9. |
- Fischer, Gunther, et al.
(författare)
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Biofuel production potentials in Europe: Sustainable use of cultivated land and pastures, Part II: Land use scenarios
- 2010
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Ingår i: Biomass and Bioenergy. - : Elsevier BV. - 1873-2909 .- 0961-9534. ; 34:2, s. 173-187
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Tidskriftsartikel (refereegranskat)abstract
- Europe's agricultural land (including Ukraine) comprise of 164 million hectares of cultivated land and 76 million hectares of permanent pasture. A "food first" paradigm was applied in the estimations of land potentially available for the production of biofuel feedstocks, without putting at risk food supply or nature conservation. Three land conversion scenarios were formulated: (i) A base scenario, that reflects developments under current policy settings and respects current trends in nature conservation and organic farming practices, by assuming moderate overall yield increases; (ii) an environment oriented scenario with higher emphasis on sustainable farming practices and maintenance of biodiversity; and (iii) an energy oriented scenario considering more substantial land use conversions including the use of pasture land. By 2030 some 44-53 million hectares of cultivated land could be used for bioenergy feed-stock production. The energy oriented scenario includes an extra 19 million hectares pasture land for feedstocks for second-generation biofuel production chains. Available land is foremost to be found in Eastern Europe, where substantial cultivated areas can be freed up through sustainable gains in yield in the food and feed sector. Agricultural residues of food and feed crops may provide an additional source for biofuel production. When assuming that up to 50% of crop residues can be used without risks for agricultural sustainability, we estimate that up to 246 Mt agricultural residues could be available for biofuel production, comparable to feedstock plantations of some 15-20 million hectares.
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| 10. |
- Londo, Marc, et al.
(författare)
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The REFUEL EU road map for biofuels in transport: Application of the project’s tools to some short-term policy issues
- 2010
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Ingår i: Biomass and Bioenergy. - : Elsevier BV. - 1873-2909 .- 0961-9534. ; 34:2, s. 244-250
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Tidskriftsartikel (refereegranskat)abstract
- The current hot debate on biofuels calls for a balanced and realistic long-term strategy forbiofuels. The REFUEL project provides several ingredients for such a strategy. Analyses inthis project indicate that domestically produced biofuels can cover a significant share of EUfuel demand in the coming decades, with the EU-12 new member states and Ukraine asmost promising regions. This potential can be realised with residual streams and onexisting agricultural land, without conversion of e.g. nature reserves. Second generationbiofuels are essential for the long-term success of biofuels due to their superior performancein many ways. But generally, the key challenge for the near future would be how toenhance the development of biofuels in a responsible way, i.e. stimulating the productionchains with the best performance, and preventing negative impacts e.g., by paying carefulattention to possible system impacts of biofuel production such as indirect land usechanges and rising food prices. Finally, 2nd generation biofuels require specific policy: theprecursor role of 1st generation is overrated, both in technical terms as well as in their roleas market precursors. When it comes to synergies, 2nd generation biofuels might benefitmore from other developments in the energy sector, such as initiatives in co-firing ofbiomass for (heat and) power, than from 1st generation biofuels, also because of the publicresistance that the latter induce.
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