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Träfflista för sökning "WFRF:(van Bavel Bert) srt2:(2015-2019)"

Sökning: WFRF:(van Bavel Bert) > (2015-2019)

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1.
  • Ax, Erika, et al. (författare)
  • Circulating levels of environmental contaminants are associated with dietary patterns in older adults
  • 2015
  • Ingår i: Environment International. - Oxford, United Kingdom : Elsevier. - 0160-4120 .- 1873-6750. ; 75, s. 93-102
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Food intake contributes substantially to our exposure to environmental contaminants. Still, little is known about our dietary habits' contribution to exposure variability.Objective: The aim of this study was to assess circulating levels of environmental contaminants in relation to predefined dietary patterns in an elderly Swedish population.Methods: Dietary data and serum concentrations of environmental contaminants were obtained from 844 70-year-old Swedish subjects (50% women) in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Dietary data from 7-day food records was used to assess adherence to a Mediterranean-like diet, a low carbohydrate-high protein diet and the WHO dietary recommendations. Circulating levels of 6 polychlorinated biphenyl markers, 3 organochlorine pesticides, 1 dioxin and 1 polybrominated diphenyl ether, the metals cadmium, lead, mercury and aluminum and serum levels of bisphenol A and 4 phthalate metabolites were investigated in relation to dietary patterns in multivariate linear regression models.Results: A Mediterranean-like diet was positively associated with levels of several polychlorinated biphenyls (118, 126, 153, and 209), trans-nonachlor and mercury. A low carbohydrate-high protein diet was positively associated with polychlorinated biphenyls 118 and 153, trans-nonachlor, hexachlorobenzene and p, p'-dichlorodiphenyldichloroethylene, mercury and lead. The WHO recommended diet was negatively related to levels of dioxin and lead, and borderline positively to polychlorinated biphenyl 118 and trans-nonachlor.Conclusion: Dietary patterns were associated in diverse manners with circulating levels of environmental contaminants in this elderly Swedish population. Following the WHO dietary recommendations seems to be associated with a lower burden of environmental contaminants.
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2.
  • Bjurlid, Filip, 1978- (författare)
  • Polybrominated dibenzo-p-dioxins and furans : from source of emission to human exposure
  • 2018
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Brominated flame retardants (BFRs), which are ubiquitous in modern life and the environment, are the major source for polybrominated dibenzo-p-dioxins and furans (PBDD/Fs). The knowledge about PBDD/Fs is lim-ited compared to other environmental pollutants, even though PBDD/Fs show similar toxicity as polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) which are considered to be among the most toxic man-made substances. The aim of the thesis was to provide a better understanding of PBDD/Fs by investigating the occurrence and distribution of PBDD/Fs in the following matrices: soot and gas from an accidental fire site which is a typical source of emission, blubber from marine mammals living in both far remote areas as well as areas close to anthropogenic sources, and finally in human milk from ten nursing mothers.PBDD/Fs was detected in blubber from pilot whales sampled around Faroe Islands, which proved the occurrence in marine mammals in a far remote area. The findings of PBDD/Fs in blubber from Baltic ringed seals showed slightly higher concentrations compared to the pilot whales, which is expected since the Baltic Sea in among the world’s most contam-inated water areas. In the pilot whales and the ringed seals, the average contribution from PBDD/Fs to the total (PCDD/F+PBDD/F) Total Equiv-alent Quantity (TEQ) was low, (1-8%). In gas and soot samples from the accidental fire site, PBDD/Fs were detected in all samples and the contri-bution of PBDD/Fs to the total TEQ was close to 100%. In the human milk samples, PBDD/Fs were detected in all samples and the average con-tribution of PBDD/Fs to the total TEQ was 40%. The results indicate that PBDD/Fs are of concern for human exposure, and should be monitored together with PCDD/Fs in future studies. Moreover, the occurrence at ac-cidental fire sites indicate that PBDD/Fs are a source for occupational ex-posure for firefighters and other professionals. The impact from PBDD/Fs on marine mammalians seems to be of less concern.
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3.
  • Chatzidaki, Maria D., 1985- (författare)
  • Formulation and characterization of W/O nano-dispersions for bioactive delivery applications
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The main objective of this study was the formulation of food-grade water-in-oil (W/O) nano-dispersions based mainly on medium or long-chain triglycerides. Two types of dispersions were formulated and structurally compared, namely emulsions and microemulsions. The systems were used as matrices for encapsulating targeted bioactive molecules with specific characteristics such as antioxidants or peptides.The structural characterization of the formulated systems was investigated using techniques such as Electron Paramagnetic Resonance (EPR) spectroscopy, Dynamic Light Scattering (DLS), Cryogenic Transmission Electron Microscopy (Cryo-TEM) and Small Angle Xray Scattering (SAXS). The existence of swollen inverse micelles was revealed for the case of microemulsions whereas larger droplets still at the nano-scale were observed for the case of emulsions. Structural differences in the presence of the bioactive molecules or induced by the alteration of components were also observed.In order to study the efficacy of the formulations, the proposed loaded systems were assessed either using EPR spectroscopy or Well Diffusion Assay (WDA) depending on the bioactive molecule. It was found that the encapsulated molecules retained their claimed characteristics when encapsulated to the proposed matrices.Finally, some of the formulated dispersions were investigated for their behavior under gastrointestinal (GI) conditions. A two-step digestion model using recombinant Dog Gastric Lipase (rDGL) and Porcine Pancreatic Lipase (PPL) was proposed to simulate lipid hydrolysis in humans. The studies revealed significant decrease of the rDGL specific activity in the presence of the microemulsion while in the presence of lower percent of surfactants (case of emulsion) no alterations were observed.
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5.
  • Eriksson, Ulrika, 1972- (författare)
  • Contribution of polyfluoroalkyl phosphate esters (PAPs) and other precursor compounds to perfluoroalkyl carboxylates (PFCAs) in humans and the environment
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Per-and polyfluoroalkyl substances (PFAS) are anthropogenic compounds that have been spread all over the world. The use of fluorotelomer compounds, short-chained homologues, and other PFASs with perfluorinated moieties has emerged recent years. One of these emerging compound classes is polyfluoroalkyl phosphate esters (PAPs), which have the ability to degrade into persistent PFCAs.The aim of this thesis was to assess the contribution of PAPs and other precursors to the exposure of PFCAs to humans and the environment. The main objective was to analyze a wide range of PFAS in human serum, wild bird eggs, indoor dust, waste water, and sludge. There was a significant contribution from selected precursors to the total amount of PFASs in the abiotic compartments indoor dust, waste water, and sludge. Levels of PAPs found in house dust exceeded those of PFCAs and perfluorosulfonic acids (PFSAs), revealing PAPs as a world-wide important exposure source.A net increase was during waste water treatment was observed for several PFASs in Swedish waste water treatment plants. Together with presence of precursor compounds and intermediates in the influent water and the sludge, this suggest that degradation of PFCA precursors contributed to the increase of PFCAs. Detection of precursors in human serum, together with slow declining trends of PFCAs, revealed an ongoing exposure of PFCAs to the general population of Australia. The diPAPs and the FTSAs were also detected in raptor bird eggs from Sweden from both the terrestrial and the freshwater environment. The precursors concentrations and patterns observed reveal that current regulatory measures are insufficient for the purpose of protecting humans and the environment from PFASs exposure.
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7.
  • Geng, Dawei, 1986-, et al. (författare)
  • Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum
  • 2016
  • Ingår i: Journal of Chromatography A. - Amsterdam, Netherlands : Elsevier. - 0021-9673 .- 1873-3778. ; 1453, s. 88-98
  • Tidskriftsartikel (refereegranskat)abstract
    • A method using a novel atmospheric pressure chemical ionization source for coupling gas chromatography (GC/APCI) to triple quadrupole mass spectrometry (MS/MS) for the determination of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) regulated by the Stockholm Convention is presented. One microliter injection of a six-point calibration curve of native PCBs and OCPs, ranging from 0.04 to 300 pg/μL, was performed. The relative standard deviation (RSD) of the relative response factors (RRFs) was less than 15% with a coefficient of determination (r2) >0.995. Meanwhile, two calibration solutions (CS), CS 2 (0.4 pg/μL) and CS 3 (4 pg/μL) were analyzed to study the repeatability calculated for both area and RRFs. The RSD for RRF ranged from 3.1 to 16% and 3.6 to 5.5% for CS 2 and CS 3, respectively. The limits of detection (LOD) determined by peak-to-peak signal-to-noise ratio (S/N) of 3 were compared between the GC/APCI/MS/MS and a GC coupled to high resolution mass spectrometry (GC/HRMS) system. GC/APCI/MS/MS resulted in lower LOD for most of the compounds, except for PCB#74, cis-chlordane and trans-chlordane. GC/APCI/MS/MS and GC/HRMS were also compared by performing analysis on 75 human serum samples together with eight QA/QC serum samples. The comparison between GC/APCI/MS/MS system and GC/HRMS system for 16 of the targeted compounds was carried out. No statistically significant difference was discovered. Due to increased sensitivity and user friendly operation under atmospheric pressure, GC/APCI/MS/MS is a powerful alternative technique that can easily meet the specification of GC/HRMS.
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8.
  • Geng, Dawei, 1986- (författare)
  • Gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry methods for the determination of environmental contaminants
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The recent developments and improvements of instrumental methods for the analyses of the environmental contaminants, especially the persistent organic pollutants (POPs), have made it possible to detect and quantify these at very low concentrations in environmental and biotic matrices.The main objective of this thesis is to demonstrate the capability of the atmospheric pressure chemical ionization technique (APCI), using gas chromatography coupled to tandem mass spectrometry for the determination of a wide range of environmental contaminants, including the POPs regulated by Stockholm Convention, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), but also the derivates of PBDEs and novel brominated flame retardants (NBFRs).The APCI was operated in charge transfer condition, preferably producing molecular ions. Multiple reaction monitoring (MRM) experiments were optimized by adjusting cone voltage, collision energy and dwell time. Optimization of source parameters, such as gas flows and temperatures was also performed. Low concentration standards were analyzed, achieving a visible chromatographic peak for 2 fg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) demonstrating the excellent sensitivity of the system. Adequate linearity and repeatability were observed for all the studied compounds. The performance of APCI methods was validated against the conventional methods using gas chromatography coupled to high resolution mass spectrometry for chlorinated compounds in a wide range of matrices including environmental, air, human and food matrices.The GC-APCI-MS/MS method was successfully applied to a set of 75 human serum samples to study the circulating levels of POPs in epidemiologic studies. Moreover the method was utilized to establish temporal trends of POPs in osprey eggs samples collected during the past five decades.
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10.
  • Hassellöv, Martin, et al. (författare)
  • Progress towards monitoring of microlitter in Scandinavian marine environments
  • 2018
  • Ingår i: TemaNord, 2018, 551, 2018. - Copenhagen : Nordic Council of Ministers.
  • Tidskriftsartikel (refereegranskat)abstract
    • Four different case studies were carried out to determine dominating microlitter types from urban environments to the regional Scandinavian seas (eastern North Sea). The sampling was both from sediment near sources (urban runoff and road dust sediment), and further out from coastal sediments. The sea surface layer and subsurface samples was taken in two different gradients, in the Oslo and Roskilde fjords, where also blue mussels were sampled. Best available technologies for sampling each compartment was used and evaluated, and while the water samples was analysed as collected, the sediment and biota samples needed some pretreatment of chemical digestion and/or heavy density liquid floatation or elutriation.In order to develop visual identification as objective as possible, a visual and physical observation scheme was proposed. The visual identification scheme should be complemented with spectroscopic identification to different degrees depending on the size fractions.Spectroscopic identification is still often a quite time-consuming process, meaning that for monitoring purposes it is not currently advisable to aim to identify all particles during monitoring studies. Until fully or partly automated spectroscopic methods are available they are still important tools for verification of representative types of particles in samples above 100 μm.The amount of particles that should be identified to provide adequate compositional information would be dependent on the aim of the study as well as the type and composition of the samples. However, in order to do monitoring and include sample composition in the results a minimum of 100 of the fewest particles should be counted in a sample to achieve 10% standard deviation in terms of counting statistical uncertainty.The field is however rapidly evolving, and automated procedures are already being published. For research purposes and more detailed monitoring and screening studies spectroscopic methods can aside from providing particle identification also give clues on additives and level of degradation.The most common types of microlitter found varied between studies but common trends could be identified between the road tunnel sediment and the urban creek sediment that these contained black particles resembling tire rubber from both visual and tactile tests, and also asphalt, charcoal, oil/tar particles and road marker particles. In the coastal water samples the surface layer was dominated by polystyrene foam particles and polyethylene fragments and films.In the subsurface water samples fibres, films and fragments of plastic was most common. In both the Gothenburg urban creek sediment and Oslo fjord surface water samples particles that could be related to artificial sports turf (polyethylene green grass and clear cut, tire granulate) was observed. The microlitter in mussels was dominated by fibres. The approach of using gradient studies, and include both near source sampling as well as recipient gradient sampling, was concluded to be very suitable to determine sources and fate.
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