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Genetic architectur...
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
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Young, WJ (author)
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Haessler, J (author)
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Benjamins, JW (author)
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show more...
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Repetto, L (author)
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Yao, J (author)
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Isaacs, A (author)
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Harper, AR (author)
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Ramirez, J (author)
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Garnier, S (author)
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van Duijvenboden, S (author)
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Baldassari, AR (author)
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Concas, MP (author)
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Duong, T (author)
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Foco, L (author)
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Isaksen, JL (author)
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Mei, H (author)
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Noordam, R (author)
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Nursyifa, C (author)
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Richmond, A (author)
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Santolalla, ML (author)
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Sitlani, CM (author)
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Soroush, N (author)
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Theriault, S (author)
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Trompet, S (author)
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Aeschbacher, S (author)
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Ahmadizar, F (author)
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Alonso, A (author)
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Brody, JA (author)
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Campbell, A (author)
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Correa, A (author)
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Darbar, D (author)
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De Luca, A (author)
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Deleuze, JF (author)
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Ellervik, C (author)
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Fuchsberger, C (author)
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Goel, A (author)
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Grace, C (author)
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Guo, XQ (author)
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Hansen, T (author)
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Heckbert, SR (author)
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Jackson, RD (author)
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Kors, JA (author)
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Lima-Costa, MF (author)
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Linneberg, A (author)
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Macfarlane, PW (author)
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Morrison, AC (author)
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Navarro, P (author)
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Porteous, DJ (author)
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Pramstaller, PP (author)
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Reiner, AP (author)
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Risch, L (author)
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Schotten, U (author)
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Shen, X (author)
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Sinagra, G (author)
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Soliman, EZ (author)
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Stoll, M (author)
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Tarazona-Santos, E (author)
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Tinker, A (author)
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Trajanoska, K (author)
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Villard, E (author)
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Warren, HR (author)
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Whitsel, EA (author)
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Wiggins, KL (author)
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Arking, DE (author)
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Avery, CL (author)
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Conen, D (author)
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Girotto, G (author)
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Grarup, N (author)
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Hayward, C (author)
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Jukema, JW (author)
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Mook-Kanamori, DO (author)
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Olesen, MS (author)
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Padmanabhan, S (author)
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Psaty, BM (author)
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Pattaro, C (author)
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Ribeiro, ALP (author)
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Rotter, JI (author)
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Stricker, BH (author)
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van der Harst, P (author)
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van Duijn, CM (author)
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Verweij, N (author)
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Wilson, JG (author)
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Orini, M (author)
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Charron, P (author)
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Watkins, H (author)
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Kooperberg, C (author)
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Lin, HJ (author)
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Wilson, JF (author)
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Kanters, JK (author)
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Sotoodehnia, N (author)
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Mifsud, B (author)
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Lambiase, PD (author)
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Tereshchenko, LG (author)
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Munroe, PB (author)
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- 2023-03-14
- 2023
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 1411-
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https://doi.org/10.1...
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Abstract
Subject headings
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- The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Young, WJ
-
Haessler, J
-
Benjamins, JW
-
Repetto, L
-
Yao, J
-
Isaacs, A
-
show more...
-
Harper, AR
-
Ramirez, J
-
Garnier, S
-
van Duijvenboden ...
-
Baldassari, AR
-
Concas, MP
-
Duong, T
-
Foco, L
-
Isaksen, JL
-
Mei, H
-
Noordam, R
-
Nursyifa, C
-
Richmond, A
-
Santolalla, ML
-
Sitlani, CM
-
Soroush, N
-
Theriault, S
-
Trompet, S
-
Aeschbacher, S
-
Ahmadizar, F
-
Alonso, A
-
Brody, JA
-
Campbell, A
-
Correa, A
-
Darbar, D
-
De Luca, A
-
Deleuze, JF
-
Ellervik, C
-
Fuchsberger, C
-
Goel, A
-
Grace, C
-
Guo, XQ
-
Hansen, T
-
Heckbert, SR
-
Jackson, RD
-
Kors, JA
-
Lima-Costa, MF
-
Linneberg, A
-
Macfarlane, PW
-
Morrison, AC
-
Navarro, P
-
Porteous, DJ
-
Pramstaller, PP
-
Reiner, AP
-
Risch, L
-
Schotten, U
-
Shen, X
-
Sinagra, G
-
Soliman, EZ
-
Stoll, M
-
Tarazona-Santos, ...
-
Tinker, A
-
Trajanoska, K
-
Villard, E
-
Warren, HR
-
Whitsel, EA
-
Wiggins, KL
-
Arking, DE
-
Avery, CL
-
Conen, D
-
Girotto, G
-
Grarup, N
-
Hayward, C
-
Jukema, JW
-
Mook-Kanamori, D ...
-
Olesen, MS
-
Padmanabhan, S
-
Psaty, BM
-
Pattaro, C
-
Ribeiro, ALP
-
Rotter, JI
-
Stricker, BH
-
van der Harst, P
-
van Duijn, CM
-
Verweij, N
-
Wilson, JG
-
Orini, M
-
Charron, P
-
Watkins, H
-
Kooperberg, C
-
Lin, HJ
-
Wilson, JF
-
Kanters, JK
-
Sotoodehnia, N
-
Mifsud, B
-
Lambiase, PD
-
Tereshchenko, LG
-
Munroe, PB
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show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet