| 1. |
- Beck, J. J., et al.
(författare)
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Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight
- 2021
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 30:19, s. 1894-1905
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Tidskriftsartikel (refereegranskat)abstract
- Birth weight (BW) is an important predictor of newborn survival and health and has associations with many adult health outcomes, including cardiometabolic disorders, autoimmune diseases and mental health. On average, twins have a lower BW than singletons as a result of a different pattern of fetal growth and shorter gestational duration. Therefore, investigations into the genetics of BW often exclude data from twins, leading to a reduction in sample size and remaining ambiguities concerning the genetic contribution to BW in twins. In this study, we carried out a genome-wide association meta-analysis of BW in 42 212 twin individuals and found a positive correlation of beta values (Pearson's r = 0.66, 95% confidence interval [CI]: 0.47-0.77) with 150 previously reported genome-wide significant variants for singleton BW. We identified strong positive genetic correlations between BW in twins and numerous anthropometric traits, most notably with BW in singletons (genetic correlation [r(g)]= 0.92, 95% CI: 0.66-1.18). Genetic correlations of BW in twins with a series of health-related traits closely resembled those previously observed for BW in singletons. Polygenic scores constructed from a genome-wide association study on BW in the UK Biobank demonstrated strong predictive power in a target sample of Dutch twins and singletons. Together, our results indicate that a similar genetic architecture underlies BW in twins and singletons and that future genome-wide studies might benefit from including data from large twin registers.
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| 2. |
- Wang, Y., et al.
(författare)
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MineGAN : Effective Knowledge Transfer From GANs to Target Domains With Few Images
- 2020
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Ingår i: 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). - : IEEE. - 9781728171685 ; , s. 9329-9338
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Konferensbidrag (refereegranskat)abstract
- One of the attractive characteristics of deep neural networks is their ability to transfer knowledge obtained in one domain to other related domains. As a result, high-quality networks can be trained in domains with relatively little training data. This property has been extensively studied for discriminative networks but has received significantly less attention for generative models. Given the often enormous effort required to train GANs, both computationally as well as in the dataset collection, the re-use of pretrained GANs is a desirable objective. We propose a novel knowledge transfer method for generative models based on mining the knowledge that is most beneficial to a specific target domain, either from a single or multiple pretrained GANs. This is done using a miner network that identifies which part of the generative distribution of each pretrained GAN outputs samples closest to the target domain. Mining effectively steers GAN sampling towards suitable regions of the latent space, which facilitates the posterior finetuning and avoids pathologies of other methods such as mode collapse and lack of flexibility. We perform experiments on several complex datasets using various GAN architectures (BigGAN, Progressive GAN) and show that the proposed method, called MineGAN, effectively transfers knowledge to domains with few target images, outperforming existing methods. In addition, MineGAN can successfully transfer knowledge from multiple pretrained GANs. Our code is available at: https://github.com/yaxingwang/MineGAN.
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| 3. |
- Wang, Y., et al.
(författare)
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Semi-Supervised Learning for Few-Shot Image-to-Image Translation
- 2020
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Ingår i: 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). - : IEEE. - 9781728171685 ; , s. 4452-4461
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Konferensbidrag (refereegranskat)abstract
- In the last few years, unpaired image-to-image translation has witnessed Remarkable progress. Although the latest methods are able to generate realistic images, they crucially rely on a large number of labeled images. Recently, some methods have tackled the challenging setting of few-shot image-to-image ranslation, reducing the labeled data requirements for the target domain during inference. In this work, we go one step further and reduce the amount of required labeled data also from the source domain during training. To do so, we propose applying semi-supervised learning via a noise-tolerant pseudo-labeling procedure. We also apply a cycle consistency constraint to further exploit the information from unlabeled images, either from the same dataset or external. Additionally, we propose several structural modifications to facilitate the image translation task under these circumstances. Our semi-supervised method for few-shot image translation, called SEMIT, achieves excellent results on four different datasets using as little as 10% of the source labels, and matches the performance of the main fully-supervised competitor using only 20% labeled data. Our code and models are made public at: https://github.com/yaxingwang/SEMIT.
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