| 1. |
- Hollestelle, Antoinette, et al.
(författare)
-
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
-
Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
|
|
| 2. |
|
|
| 3. |
- Ferm Almqvist, Cecilia, et al.
(författare)
-
Collaborative learning as common sense : structure, roles and participation amongst doctoral students and teachers in music education – beyond communities of practice
- 2017
-
Ingår i: Visions of Research in Music Education. - New Jersey : The New Jersey Music Educators Association. - 1938-2065. ; 29:1
-
Tidskriftsartikel (refereegranskat)abstract
- The article communicates an investigation ofhow collaborative learning is constituted in a PhD-course, namely Collaborative learning in music educational settings. The course was organized and run in a way that wished to investigate, develop and encourage collaborative learning among students and teachers at postgraduate level. Material produced and analysed included logbooks, assignments, peer-response, after-thoughts, and a Facebook discussion-thread. The results are presented as descriptions of the constituent parts of collaborative learning occurring in the “rooms” of the course. The results show the importance of structure as well as awareness when it comes to roles and kinds of participation.
|
|
| 4. |
- Ferm, Cecilia, et al.
(författare)
-
Collaborative learning as common sense: structure, roles and participation amongst doctoral students and teachers in music education : beyond communities of practice
- 2017
-
Ingår i: Visions of Research in Music Education. - : New Jersey Music Educators Association. - 1938-2065. ; 29
-
Tidskriftsartikel (refereegranskat)abstract
- The article communicates an investigation of how collaborative learning is constituted in a PhD-course, namely Collaborative learning in music educational settings. The course was organized and run in a way that aimed to investigate, develop and encourage collaborative learning among students and teachers in the third circle. Material produced and analysed included log-books, assignments, peer-response, after-thoughts, and a Facebook discussion-thread. The results are presented as descriptions of the constituent parts of collaborative learning occurring in the “rooms” of the course. The results show the importance of structure as well as awareness when it comes to roles and kinds of participation.
|
|
| 5. |
|
|
| 6. |
- Kimbung, Siker, et al.
(författare)
-
Assessment of early response biomarkers in relation to long-term survival in patients with HER2-negative breast cancer receiving neoadjuvant chemotherapy plus bevacizumab : Results from the Phase II PROMIX trial
- 2018
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 142:3, s. 618-628
-
Tidskriftsartikel (refereegranskat)abstract
- Pathologic complete response (pCR) is a predictor for favorable outcome after neoadjuvant treatment in early breast cancer. Modulation of gene expression may also provide early readouts of biological activity and prognosis, offering the possibility for timely response-guided treatment adjustment. The role of early transcriptional changes in predicting response to neoadjuvant chemotherapy plus bevacizumab was investigated. One-hundred-and-fifty patients with large, operable and locally advanced HER2-negative breast cancer received epirubicin and docetaxel, with the addition of bevacizumab. Patients underwent tumor biopsies at baseline, after Cycle 2 and at the time of surgery. The primary end point, pCR, and its relation with the secondary endpoints event-free survival (EFS), overall survival (OS) and gene expression profiles, are reported. The pCR rate was 13% (95% CI 8.6-20.2), with significantly more pCRs among triple-negative [28% (95% CI 14.8-45.4)] than among hormone receptor positive (HR+) tumors [9% (95% CI 4.6-16.3); (OR=3.9 [CI=1.5-10.3])]. pCR rates were not associated with EFS or OS. PAM50 subtypes significantly changed after Cycle 2 (p=0.03) and an index of absolute changes in PAM50 correlations between these time-points was associated with EFS [HR=0.62 (CI=0.3-1.1)]. In univariable analyses, signatures for angiogenesis, proliferation, estrogen receptor signaling, invasion and metastasis, and immune response, measured after Cycle 2, were associated with pCR in HR+ tumors. Evaluation of changes in molecular subtypes and other signatures early in the course of neoadjuvant treatment may be predictive of pCR and EFS. These factors may help guide further treatment and should be considered when designing neoadjuvant trials.
|
|
| 7. |
- Morén, Sol, 1964-
(författare)
-
Relational creativity : what can participatory art do for higher education?
- 2019
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Why research creativity in higher education? Creativity is regarded as a key competence for future education by the European Union as well as by UNESCO, and my wish is to contribute to this contemporary global agenda of rethinking education. Creativity is central for complex problem- solving and we need to rethink education to facilitate for our future citizens to develop creativity, to be able to meet our interconnected world's urgent need for sustainable development. Based on these global demands for supporting creativity as a competence in future education, I propose that developing knowledge about design for creative learning environments is an important quest in educational research.The problem however, is that, there is not much previous research that can serve as a knowledge foundation for how to design for learning environments which support students' development of creativity. In this thesis I research creativity from a sociorelational perspective, with and through participatory artistic practices. I first came to think of the notion of relational creativity, while working as an artist, noticing how there seemed to be a connection between participants' increased creativity and engagement in participatory artistic practices.The aim of the thesis is to develop theory about relational creativity as a design concept for creative learning environments, grounded in practice. The study is based on my previous research and development work as an artist-in-residence in higher education. In the thesis the theory is presented along with four design concepts for relational creativity. The four design concepts are: design for creative transformation - as in taking advantage of art's openness for interpretation and emergence of unexpected new solutions; design for creative participation - as in trusting the participants with the responsibility of contributing to a common work of art and knowledge; design for creative comparative encounters - as in providing participants with supportive environments free from judgmental evaluation; design for creative networking - as in facilitating for participants to share, interact with and contribute to each other's processes of art and meaning making. In the thesis I present theory along with rich empirical examples reconnecting to the participatory artistic interventions which this study is based on. My ambition to contribute with new knowledge about relational creativity as a design concept for creative learning environments in higher education, which is useful for practitioners as well as for the research community.
|
|
| 8. |
|
|
| 9. |
- Thorgersen, Ketil, 1972-, et al.
(författare)
-
Allt annat än tyst kunnande... : Vad är kunskap i Black metal?
- 2017
-
Ingår i: Book of Abstract. - Umeå : Umeå universitet. ; , s. 14-14
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Black metal är en extrem sub-genre såväl estetiskt som ideologiskt inom den större genren Heavy metal. Det som kännetecknar Black metal är fokus på förmedling av mänsklighetens mörkaste sidor. Artisterna inom genren förespråkar och företräder satanism och ockultism med en strävan efter att sprida känslor av obehag, rädsla, mörker och ondska. Estetiskt gör de detta genom ett paket av emotiva funktioner där disharmonisk musik samverkar med ett visuellt och berättande uttryck i något som kan betraktas som ett “Gesamtkunstwerk”. Musikaliskt skapas detta ofta genom growl-song i ett lite högre register där ovannämnda teman är centrala i texterna. Gitarr- och bassoundet kännetecknas av mer eller mindre kraftig distorsion och trummorna av högt tempo genom så kallade “blast beats” (väldigt snabbt spel som kan påminna om maskingevär). Harmoniskt komponeras musiken lika ofta horisontellt (polyfont), såsom var brukligt exempelvis under barocken, som vertikalt som i nästan all populärmusik. Ett horisontellt komponerande hjälper till i sökandet efter disharmoni. Det musikaliska uttrycket kan, förutom i texterna, påminna om andra sub-genrer såsom Death metal. Dock hörsammar en initierad lyssnare tydliga skiljelinjer som t.ex att vokalister inom Black metal-genren growlar i högre register och att Black metal-band sällan stämmer ner sina gitarrer.Norden är och har historiskt varit det starkaste fästet för Black metal och tusentals unga människor lär sig om musiken, livet och döden genom att insocialiseras i genren. I denna presentationen tar vi vårt primära utgångspunkt i empiri från fem intervjuer med unga Black metal-musiker som berättar om sitt syn på genren, vilken betydelse den har (haft) i deras liv och hur lärandet och socialiserandet har gått till. Kombinerat med detta har fanziner, tidskrifter inom genren samt böcker och forskning om genren ingått.Lärandet i Black metal är i allt väsentligt icke-institutionellt och följer dels en traditionell garagebandslogik, men även en bildningsliknande självförädlande process enligt deltagarna. Kunskapen är inte formellt beskriven som ett kanon, men kunskapsutvecklingen inom fältet rör sig i en spänning mellan tradition och nyskapande som deltagarna beaktar på olika sätt. Vad som anses vara värdefull kunskap ser därför olika ut. Men är det tyst?Det tysta kunnandet skriks ut i syfte att skrämma livet ur dig...
|
|
| 10. |
- Thorgersen, Ketil, 1972-, et al.
(författare)
-
Becoming extreme : A media analysis of how music is constructed in three marginalised/outsider groups’ fanzines
- 2017
-
Ingår i: Abstracts NNMPF 2017. ; , s. 12-13
-
Konferensbidrag (refereegranskat)abstract
- Music and and art is often considered to help good people. On the internet and in newspapers we can find lots of debates and articles about how the world would be a better place if only the arts played a more prominent role in education. In this paper we will investigate the other side of the coin. Considering that Mussolini was an accomplished violinist, Hitler and Franco both were talented painters and Mao a recognized poet. We will not assume that art leads to what the society, in general, consider as good or decent, but rather ask what role music plays in constructions of subgroups who are, by choice or by exclusion, outsiders in society. In recent years in the afterglow of the economic regression and often connected to the increased migration, more extreme groups and politicians have gained ground. We have decided to study musical socialisation in three marginalised groups who could loosely be labelled: “the Salvation Christian Movement”, “the Black Metal Movement” and “the New/Alt Right movement”. These – in every respect highly idealistic – groups have been selected to represent different angles to understand how music, ideology/religion and society intersect. The three groups also share a scepticism towards representative democracy in various forms. The groups are however different in that some seek power and influence while others seek to be more exclusive. Also the kind of ideology or belief that is at the roots of the movements are very different, as are the level of “danger” associated with the groups. The empirical material for the paper is what we label “fanzines” online and offline since 2014 that Swedish youth are likely to read. A fanzine in this meaning could be a group on social media, a physical paper, an online forum, webpage or a podcast.
|
|
