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| 2. |
- Rosengren, Agneta, et al.
(författare)
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Analysis of the inflammatory response to titanium and PTFE implants in soft tissue by macrophage phenotype quantification
- 1998
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Ingår i: Journal of Materials Science: Materials in Medicine. - 1573-4838. ; 9:7, s. 415-420
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Tidskriftsartikel (refereegranskat)abstract
- Implants of commercially pure titanium and polytetrafluoroethylene (PTFE) were inserted in the rat abdominal wall for 1, 6 or 12 wk. The foreign body reaction was evaluated by immunohistochemical quantification of monocytes/macrophages and by the thickness of the foreign-body capsule. At all time intervals, the majority of interfacial cells were ED1-positive while ED2-positive cells were localized deeper in the tissue. Neither titanium nor PTFE displayed a significant change in capsule thickness over time. The total cell numbers decreased overtime for both types of material. At 12 wk the PTFE implants, compared to titanium, were surrounded by a significantly thicker reactive capsule with larger total cell numbers. No significant differences were seen in the macrophage subset response between the two types of implants. Thus, the present study showed differences between titanium and PTFE at 12 wk but not at earlier time points.
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| 3. |
- Rosengren, Agneta, et al.
(författare)
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Tissue reactions to polyethylene implants with different surface topography
- 1999
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Ingår i: Journal of Materials Science: Materials in Medicine. - 1573-4838. ; 10:2, s. 75-82
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates the importance of implant surface topography on soft tissue response. The tissue response in the rat abdominal wall to discs of low density polyethylene with smooth to coarse surfaces was evaluated after one, six or 12 weeks. Capsule thickness and immunohistochemical quantification of monocytes-macrophages were used as measures. The macrophage specific antibody ED1 was used for identification of newly recruited macrophages and the ED2 antibody for the mature tissue macrophages. The smoother surfaces gave a thicker capsule than the rougher surfaces, and at one week also larger total numbers of cells and ED1 positive macrophages at interface. The capsule thickness increased over time for the smooth and intermediate surface topographies. In contrast, the cell numbers generally decreased over time. In conclusion, a coarse surface elicited lesser tissue reaction compared with a smooth surface.
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| 4. |
- Terada, N, et al.
(författare)
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The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures
- 1997
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Ingår i: Journal of Materials Science: Materials in Medicine. - 1573-4838. ; 8:6, s. 391-394
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Tidskriftsartikel (refereegranskat)abstract
- A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon]) or resorbable materials (polydioxanon [PDS], polyglactin [Vicryl] or catgut). The purpose was to study the tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the filament surface mainly consisted of ED1 positive cells and their thickness depends on the filament materials.
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