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Träfflista för sökning "hsv:(MEDICAL AND HEALTH SCIENCES) hsv:(Clinical Medicine) hsv:(Hematology) srt2:(1980-1989)"

Search: hsv:(MEDICAL AND HEALTH SCIENCES) hsv:(Clinical Medicine) hsv:(Hematology) > (1980-1989)

  • Result 1-10 of 29
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2.
  • Sabharwal, Hemant, et al. (author)
  • Oligosaccharides from faeces of a blood-group B, breast-fed infant
  • 1988
  • In: Carbohydrate Research. - : Elsevier BV. - 1873-426X .- 0008-6215. ; 178:1, s. 145-154
  • Journal article (peer-reviewed)abstract
    • Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active.
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3.
  • Sabharwal, Hemant, et al. (author)
  • Oligosaccharides from feces of preterm infants fed on breast milk
  • 1988
  • In: Archives of Biochemistry and Biophysics. - : Elsevier BV. - 0003-9861. ; 265:2, s. 390-406
  • Journal article (peer-reviewed)abstract
    • Nine neutral and five acidic oligosaccharides were isolated from feces of a preterm (30th postmenstrual week) blood group A nonsecretor infant fed on pooled breast milk. Structural analyses were carried out using sugar and methylation analyses, fast atom bombardment mass spectrometry, and 1H NMR. The acidic oligosaccharides are well-known components of human milk. The neutral oligosaccharides are characteristic of nonsecretor milk. Surprisingly, no secretor gene-dependent oligosaccharides were present in the feces. Another preterm (27th postmenstrual week) blood group A, secretor infant fed on pooled breast milk showed the same fecal oligosaccharide pattern as above during the first week after birth, despite being a secretor individual. Also notable was the absence of blood group A-active oligosaccharides in this sample. Another sample of feces collected 8 weeks later from the latter infant contained the expected blood group A-active oligosaccharides. Furthermore, free sialic acid was present at the cost of the sialyl oligosaccharides seen earlier. Thus, infants born prematurely do not show the same degree of development of oligosaccharide metabolism as their more mature counterparts.
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4.
  • Ankerst, J., et al. (author)
  • Microcalorimetry as a tool for the detection of complement-dependent cytotoxicity
  • 1985
  • In: Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 77:2, s. 267-274
  • Journal article (peer-reviewed)abstract
    • Microcalorimetry using a 4-channel static ampoule microcalorimeter of thermopile type has been evaluated as a tool for the detection of complement-dependent cytotoxicity against the surface antigens of living cells. Cytotoxic reactions mediated by a rabbit antiserum against human white blood cells and by 2 different monoclonal antibodies recognizing a melanoma-associated antigen on a human melanoma cell line were studied. The cytotoxic reactions were registered as a decrease of the heat production rate when the cells were exposed to antibodies in the presence of active complement as compared to the heat production rate of the cells exposed to the same antibodies in the presence of inactive complement. This investigation shows that microcalorimetry can be used as a highly sensitive method for the detection of complement-dependent immune reactions, detecting antibody dilutions higher than 10-5. It also indicates that microcalorimetry may become a particularly important technique in the analysis of the kinetics of cytotoxic immune reactions in vitro.
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5.
  • Fäldt, R., et al. (author)
  • Inhibition of platelet aggregation by myeloid leukaemic cells demonstrated in vitro
  • 1987
  • In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 66:4, s. 529-534
  • Journal article (peer-reviewed)abstract
    • The effect of myeloid leukaemic cells, cells of the promyelocytic cell line HL-60 and normal polymorphonuclear granulocytes (PMN), enclosed in dialysis tubes, on the aggregation of allogeneic normal platelets after induction with arachidonic acid (AA) and with adenosine diphosphate (ADP) was investigated in vitro. Inhibition of aggregation was seen after preincubation of the platelets with leukaemic blood or bone marrow cell from 7/14 patients belonging to various FAB groups and with HL-60, but not with normal PMN (14/14 cases). A dose-dependent inhibition was seen after lysis of some leukaemic cells with anti-human rabbit antiserum and active complement. Lysis of normal PMN inhibited platelet aggregation slightly and inconstantly and only at higher cell concentrations. Platelet inhibitory activity was not related to a higher rate of metabolism of the leukaemic cells which inhibited platelet aggregation with respect to heat production. Neither was a non-specifically increased cell membrane permeability the cause of the release of platelet inhibitory factor(s) since the release of 51Cr-labeled leukaemic cells was not related to the inhibition of platelet aggregation.
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9.
  • Arvidsson, J, et al. (author)
  • The first case of the Sanfilippo type C syndrome in Scandinavia
  • 1983
  • In: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 72:2, s. 313-316
  • Journal article (peer-reviewed)abstract
    • A Swedish patient with typical symptoms of the Sanfilippo Syndrome (Mucopolysaccharidosis III) is described. The early onset of the disease, the presence of hepatomegaly, early dementia and the absence of umbilical bernia are consistent with the subgroup Sanfilippo A. Enzyme studies indicate the diagnosis Sanfilippo C, and thus the patient represents a more severe form of this subgroup than any of the four other patients hitherto described in detail.
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10.
  • Faldt, R., et al. (author)
  • Heat production in different populations of human blood cells exposed to immune complexes in vitro : The importance of the Fc parts of immunoglobulins and the influence of active complement
  • 1982
  • In: Immunology. - 0019-2805. ; 46:1, s. 189-198
  • Journal article (peer-reviewed)abstract
    • By use of a batch microcalorimeter of the thermopile type, heat production was measured in isolated populations of human peripheral blood cells exposed to defined immune complexes formed in vitro. It was found that most of the heat production recorded in whole blood after admixture of immune complexes occurs in the granulocytes. Under these conditions small but constantly higher activation values were found in the absence of active complement. It was shown that complexes consisting of antigen and F(ab)2 fragments prepared from the specific antibodies were able to initiate heat production in the cells only in the presence of active complement. These experiments indicate that immune complexes are able to induce increased heat production in the cells either by binding to Fc receptors or by activation of complement through the alternative pathway and subsequent binding of the generated C3b to C3b receptors on the heat-producing cells.
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  • Result 1-10 of 29

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