| 1. |
- Riise, Gerdt C., 1956, et al.
(författare)
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Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis
- 1994
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Ingår i: Eur Respir J. - 0903-1936. ; 7:9, s. 1673-1677
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Tidskriftsartikel (refereegranskat)abstract
- The initial phase of inflammation in bronchial asthma appears to be triggered by the expression of leucocyte-endothelial adhesion molecules on endothelial cell surfaces. Cell adhesion molecules (CAMs) cause adhesion of leucocytes to the endothelium prior to their subsequent extravasation into inflamed tissue. We wanted to determine whether circulating intercellular adhesion molecule-1 (cICAM-1) and circulating E-selectin (cE-selectin) could be detected in bronchial lavage fluid and serum in patients with stable chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Bronchoscopy and small volume bronchial lavage was performed in 19 patients with COPD and chronic bronchitis and in 13 control subjects. We found increased mean levels of cICAM-1 both in serum (481 micrograms.l-1) and in bronchial lavage (24 micrograms.l-1) in the COPD patients as compared to the controls (321 micrograms.l-1 in serum, 15 micrograms.l-1 in lavage). We also found higher mean levels of cE-selectin in serum from the COPD patients (86 micrograms.l-1) compared to controls (50 micrograms.l-1). The serum levels of cE-selectin correlated significantly with lung function measured as forced expiratory volume in one second (FEV1) in percentage of predicted. Patients with significant intrabronchial bacterial colonization had increased levels of serum cE-selectin. Our results indicate that cCAMs may reflect an upregulation of CAMs on endothelial and epithelial airway cells in COPD.
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| 2. |
- Bendsöe, Niels, et al.
(författare)
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Inflammatory reactions from organic pigments in red tattoos
- 1991
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Ingår i: Acta Dermato-Venereologica. - 1651-2057. ; 71:1, s. 70-73
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Tidskriftsartikel (refereegranskat)abstract
- Two different red pigments used for tattooing were found to give rise to inflammatory reactions in the skin. No inorganic component was found in the pigments. NMR and MS analyses elucidated the molecular structures of two different organic compounds. A bright red pigment was found to be an aromatic azo-derivative, and a red-violet pigment was found to be linear quinacridone. A strong exposure to UV-light was reported in most cases prior to the onset of the inflammation.
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| 3. |
- Bergendorff, Ola, et al.
(författare)
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Airborne contact dermatitis from formaldehyde released from heated plastic polymers.
- 1994
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Ingår i: American Journal of Contact Dermatitis. - 1532-8163. ; 5:4, s. 223-225
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Tidskriftsartikel (refereegranskat)abstract
- A 55-year-old woman developed an airborne dermatitis on her face. Patch testing was performed and showed positive reactions to formaldehyde, thiuram mix, carba mix, and nickel sulphate. She operated a machine at work in which polyacetal granules were heated. The presence of formaldehyde in the pyrolysis smoke from the polymer was confirmed by chemical analysis.
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| 4. |
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| 5. |
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| 6. |
- Fakler, JW, et al.
(författare)
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Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis
- 1994
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Ingår i: Human Immunology. - : Elsevier BV. - 0198-8859 .- 1879-1166. ; 40:4, s. 299-302
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Tidskriftsartikel (refereegranskat)abstract
- TAP2 is a gene, located between HLA-DP and HLA-DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in this gene. TAP2 is of particular interest because its involvement in antigen presentation makes it a candidate for a disease susceptibility gene. In psoriasis, two clinical subtypes analogous to the situation in diabetes type I with early onset and family history and type II with later onset and without family history have been described. We have previously shown that type I but not type II psoriasis is associated with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 haplotype. To investigate whether this haplotype extends to include particular TAP2 and/or DP alleles, we tested the TAP2 and HLA-DP alleles of a control group (n = 199), patients with psoriasis type I (n = 66), and patients with psoriasis type II (n = 35) by hybridization with SSOs. Our data show that there is no significant correlation between TAP2 and/or HLA-DP gene polymorphism and psoriasis type I and/or type II. We conclude that disease association in type I psoriasis is associated with the extended haplotype HLA-B57, -Cw6, -DRB1*0701/2, -DQA1*0201, -DQB1*0303.
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| 7. |
- Flinck, A, et al.
(författare)
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Oral findings in a group of newborn Swedish children.
- 1994
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Ingår i: International Journal of Paediatric Dentistry. - 0960-7439. ; 4:2, s. 67-73
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Tidskriftsartikel (refereegranskat)abstract
- Oral examinations were performed of 1021 newborn Swedish children, of whom 101 were re-examined after 2-3 or 4-5 months. The most common findings, registered in 74.9% of the children, were of oral mucosal cysts situated either palatally or on the alveolar ridges. The majority of the palatal cysts disappeared shortly after birth, and some alveolar cysts appeared after birth. Ankyloglossia was found in 2.5% of the children, and Fordyce spots in 1.0%. No natal teeth were found. The upper labial frenum was attached to the crest of the alveolar ridge in 76.7% of the children, palatally in 16.7% and buccally in 6.7%. The relationship of the alveolar ridges was recorded: the anterior segment of the mandibular ridge was distal to the maxillary in 99% of cases, and, posteriorly, the mandibular ridges were lingual to the maxillary in 97.6%. An open bite was found in 39.8% of the children.
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| 8. |
- Fransson, Lars-Åke, et al.
(författare)
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Oligosaccharide mapping of proteoglycan-bound and xyloside-initiated dermatan sulfate from fibroblasts
- 1991
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Ingår i: Glycoconjugate Journal. - 1573-4986. ; 8:2, s. 108-115
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Tidskriftsartikel (refereegranskat)abstract
- The copolymeric structure of dermatan sulfate chains synthesized by skin fibroblasts has been examined. Chains initiated onto exogeneous p-nitrophenyl-beta-D-xylopyranoside or attached to protein in a large proteoglycan, PG-L, and two small proteoglycans, PG-S1 and PG-S2, have been compared by using high resolution electrophoresis and gel chromatography of oligosaccharides generated by specific enzymatic or chemical degradations. The results confirm that chains attached to PG-L are glucuronate-rich, whereas novel findings indicate that chains attached to either of the two PG-S variants yield closely similar oligosaccharide maps, have approximately equal glucuronate and iduronate content and contain over 90% 4-sulfated disaccharide repeating units. Dermatan sulfate chains built onto xyloside at concentrations of 50 microM and below have a copolymeric structure similar to that of chains from the two PG-S variants. These findings indicate that the polymer-modifying machinery can generate chains with extended iduronate-containing repeats also when the xylose primer is not linked to core protein.
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