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| 2. |
- Buch-Rasmussen, Thomas
(creator_code:cre_t)
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A device for the administration of a liquid medicament suspension
- 1998
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- In an ampoule for a medicament the space accommodating the medicament is defined by an ampoule wall (1) a pierceable seal (5) closing one end of the ampoule and a piston (7) closing the other end of the ampoule. A metal containing fixation element (8) is secured to one of the parts defining the medicament accommodating space. A mixing element (9, 10) also containing a metal and having a density larger than 1,0 g/cm<3> is movable in medicament accommodating space. At least one of the elements, the fixation element (8) and the mixing element (9, 10), can be attracted by a magnet, and at least one of these elements is a magnetic element, the magnetic strength being so that the mixing element (9, 10) can during normal handling of the ampoule be fixed relative to this ampoule by the magnetic attraction between the fixation element (8) and the mixing element (9, 10) but may be released from its fixed position by manual operation.
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| 3. |
- Buch-Rasmussen, Thomas
(creator_code:cre_t)
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Coating system providing low friction
- 1999
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper. The coatings according to the present invention are especially suited to use for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations. The coatings providing low friction between the two components, such as a container wall and a rubber stopper, result in high-precision dosing. The described coatings are particularly useful for coating containers for storage and administration of liquid protein solutions, such as insulin formulations.
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| 4. |
- Larsson, Per-Olof, et al.
(författare)
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Superporous Agarose—A New Material for Chromatography
- 1996
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Ingår i: Advances in Molecular and Cell biology : Biochemical Technology - Biochemical Technology. - 0762301147 ; 15, s. 585-592
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Superporous particles contain two sets of pores, normal diffusion pores and very large flow pores. If such particles are used chromatographically, part of the flow will pass through each particle. This leads to a rapid equilibration between the stationary and the mobile phases, even if the superporous particle has a large outer diameter. Superporous particles are thus chromatographically efficient and at the same time give a low flow resistance, a combination of advantageous properties not found with normal chromatographic supports.
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| 5. |
- Rasmussen, Thomas-Buch
(creator_code:cre_t)
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Medical article with coated surfaces exhibiting low friction and low protein adsorption
- 1999
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.
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| 8. |
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| 9. |
- Axegard, Peter, et al.
(författare)
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Bleaching of softwood kraft pulps with H2O2, O3, and ClO2
- 1996
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Ingår i: TAPPI Journal. - 0734-1415. ; 79:1, s. 113-119
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Tidskriftsartikel (refereegranskat)abstract
- Ozone or chlorine dioxide bleaching prior to hydrogen peroxide bleaching greatly improves the performance of the hydrogen peroxide stage. The efficiency is further improved by a chelating treatment immediately after the ozone or chlorine dioxide stage. With an optimal metal ion profile, laboratory bleached (OAZQP) softwood kraft pulps can reach brightness levels above 90% ISO, with 5-10% lower pulp strength properties and bleaching costs comparable to ECF bleaching. It also is possible to obtain full brightness with only hydrogen peroxide provided the metal ion profile is optimal, e.g., by using multiple QP treatments. The chemical consumptions, expressed as oxidation equivalents per decreased kappa number are the same as for sequences including ozone or chlorine dioxide. Ozone and chlorine dioxide are comparable as far as delignification and brightness efficiency go.
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| 10. |
- Buchert, Johanna, et al.
(författare)
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Effect of pulping and bleaching on pulp carbohydrates and technical properties.
- 1996
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Ingår i: Proceedings Int. Pulp Bleaching. ; , s. 39-42
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Konferensbidrag (refereegranskat)abstract
- Pulping and bleaching have a profound effect on the carbohydrate chem. of kraft pulps. The chem. structure of xylan is modified due to the conversion of methylglucuronic acid side groups to hexenuronic acid side groups. Pulping conditions strongly affect the amt. of hexenuronic acid present in the pulp and subsequently modified kraft pulps have different carboxyl group profiles as compared with conventionally cooked pulps. Due to its reactivity, hexenuronic acid is readily degraded when chlorine dioxide or ozone are used as bleaching chems. However, TCF-pulps bleached with peroxide and oxygen contain high amts. of hexenuronic acid. Thus, depending on the pulping and bleaching method, the quality and quantity of carboxylic acids in different types of pulps varies significantly. The differences in the uronic acid content are in turn reflected in the macroscale properties of the pulps, such as brightness stability.
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