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Early treatment wit...
Early treatment with thrombolysis and betablockade in suspected acute myocardial infarction : results from the TEAHAT Study
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Risenfors, M (författare)
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- Herlitz, Johan (författare)
- [external]
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Bergh, C-H (författare)
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Dellborg, M (författare)
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Gottfridsson, C (författare)
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Gustavsson, G (författare)
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Lomsky, M (författare)
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Swedberg, K (författare)
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Hjalmarson, Å (författare)
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(creator_code:org_t)
- Wiley-Blackwell Publishing Ltd. 1991
- 1991
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell Publishing Ltd.. - 0954-6820 .- 1365-2796. ; 734:suppl 1, s. 35-42
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Independent trials of early administration of beta-blockers and thrombolytic agents have shown beneficial effects on both short- and long-term prognoses in acute myocardial infarction (AMI). The effects of a combination of the two strategies have not been thoroughly documented. Three hundred and fifty-two patients, of less than 75 years of age, with chest pain indicative of AMI, and onset less than 2 h and 45 min before first examination, were randomized to treatment with rt-PA or placebo. All patients without contraindication were given intravenous metoprolol 15 mg acutely and then 200 mg orally daily. Treatment was started either at the prehospital stage or in hospital. Thirty-seven per cent of patients had contraindications to beta-blockade, the most frequent of which were heart rate less than 60 beats min-1 and hypotension. The remaining 63% were given intravenous beta-blockade. No side-effects of metoprolol, alone or in combination with rt-PA, were observed during the prehospital phase. Overall, toleration of the treatment was good. Reduction in enzymatically estimated infarct size by rt-PA was more pronounced in patients who were also treated with metoprolol (41%, P less than 0.001) than in those with contraindications to beta-blockade (15%, NS). Patients who were also treated with metoprolol also had a lower incidence of Q-wave infarctions, congestive heart failure and ventricular fibrillation than those who were not given intravenous beta-blockade. In conclusion, toleration of intravenous administration of rt-PA and metoprolol was good, and this was also the case in the prehospital phase.
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- art (ämneskategori)
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