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Extracts of Digeste...
Extracts of Digested Berries Increase the Survival of Saccharomyces cerevisiae during H2O2 Induced Oxidative Stress
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- Oliveira, Gabriel (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Radovanovic, Natasa (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nunes, Maria Cecilia do Nascimento (författare)
- University of South Florida
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- Fristedt, Rikard, 1978 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Alminger, Marie, 1957 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Andlid, Thomas, 1963 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2021-02-18
- 2021
- Engelska.
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Ingår i: Molecules. - : MDPI AG. - 1420-3049 .- 1420-3049. ; 26:4
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://www.mdpi.com...
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https://doi.org/10.3...
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https://research.cha...
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Abstract
Ämnesord
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- Many studies suggest anthocyanins may prevent the development of several diseases. However, anthocyanin bioactivity against cellular stress is not fully understood. This study aimed to evaluate the protective effect of berry anthocyanins on stressed cells using Saccharomyces cerevisiae. The impact of in vitro gastrointestinal digestion on anthocyanin profiles was also assessed. Bilberry and blackcurrant had higher anthocyanin levels than raspberry and strawberry, but digestion reduced the detected anthocyanins by approximately 90%. Yeast cells with and without digested or nondigested anthocyanin extracts were exposed to H2O2 and examined for survival. In the presence of anthocyanins, particularly from digested strawberry, a significant increase in cell survival was observed, suggesting that the type and levels of anthocyanins are important factors, but they also need to undergo gastrointestinal (GI) structural modifications to induce cell defence. Results also showed that cells need to be exposed to anthocyanins before the stress was applied, suggesting induction of a cellular defence system by anthocyanins or their derivatives rather than by a direct antioxidative effect on H2O2. Overall, data showed that exposure of severely stressed yeast cells to digested berry extracts improved cell survival. The findings also showed the importance of considering gastrointestinal digestion when evaluating anthocyanins' biological activity.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- anthocyanins
- in vitro digestion
- berry fruits
- stress bioassay
- improved survival
- polyphenols
- yeast
- oxidative stress
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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