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Characterization of...
Characterization of infiltrating lymphocytes in human benign and malignant prostate tissue
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- Rådestad, E. (författare)
- Karolinska Institutet
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- Egevad, L. (författare)
- Karolinska Institutet
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- Jorns, C. (författare)
- Karolinska Institutet
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- Mattsson, J. (författare)
- Karolinska Institutet
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Sundberg, B. (författare)
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- Nava, S. (författare)
- Karolinska Institutet
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- Ericzon, B. -G (författare)
- Karolinska Institutet
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- Henningsohn, L. (författare)
- Karolinska Institutet
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Levitsky, V. (författare)
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- Uhlin, Michael (författare)
- KTH,Cellulär biofysik,Karolinska Institutet, Sweden
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(creator_code:org_t)
- 2017-07-24
- 2017
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals LLC. - 1949-2553. ; 8:36, s. 60257-60269
- Relaterad länk:
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Immune checkpoint blockade has shown promising results in numerous cancer types. However, in prostate cancer (PC), absent or limited responses have been reported. To investigate further, we compared the phenotype of infiltrating T-cells isolated from prostate tissue from patients with PC (n = 5), benign prostatic hyperplasia (BPH) (n = 27), BPH with concurrent PC (n = 4) and controls (n = 7). The majority of T-cells were CD8+ and had a CCR7-CD45RO+ effector memory phenotype. However, the yield of T-cells isolated from PC lesions was on average 20-fold higher than that obtained from control prostates. Furthermore, there were differences between the prostate conditions regarding the percentage of T-cells expressing several activation markers and co-inhibitory receptors. In conclusion, many prostateinfiltrating T-cells express co-inhibitory receptors PD-1 and LAG-3, regardless of prostate condition. Despite the observed increase in counts and percentages of PD- 1+ T-cells in PC, the concomitant demonstration of high percentage of PD-1+ T-cells in control prostates suggests that PD-1 may play a role in controlling the homeostasis of the prostate rather than in contributing to PC-associated immune-suppression. Thus, PD-1 may not be a good candidate for checkpoint blockade in PC and these data are relevant for evaluation of clinical trials and in designing future immunotherapeutic approaches of PC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Benign prostatic hyperplasia
- Checkpoint blockade
- PD-1
- Prostate cancer
- Prostate-infiltrating lymphocytes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rådestad, E.
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Egevad, L.
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Jorns, C.
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Mattsson, J.
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Sundberg, B.
-
Nava, S.
-
visa fler...
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Ericzon, B. -G
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Henningsohn, L.
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Levitsky, V.
-
Uhlin, Michael
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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Oncotarget
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet