Sökning: id:"swepub:oai:DiVA.org:liu-121095" >
NUCLEOSIDE ANALOG A...
NUCLEOSIDE ANALOG ACTIVITY IN MALIGNANT MELANOMA CELL LINES
-
- Fyrberg, Anna (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för läkemedelsforskning
-
- Lotfi, Kourosh (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi
-
(creator_code:org_t)
- 2015-08-07
- 2015
- Engelska.
-
Ingår i: Nucleosides, Nucleotides & Nucleic Acids. - : Taylor andamp; Francis: STM, Behavioural Science and Public Health Titles. - 1525-7770 .- 1532-2335. ; 34:9, s. 639-649
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies. Screening malignant melanoma cell lines against NAs revealed high sensitivity to several of them. This was believed to be due to the high levels of dGK expression in these cells. Downregulation of dGK in the melanoma cell line RaH5 using siRNA did not cause resistance to NAs as expected, but instead cells became more sensitive. This was probably partly due to the increased activity of another mitochondrial enzyme, thymidine kinase 2, seen in transfected cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Deoxyguanosine kinase; melanoma; leukemia; nucleoside analog; RNAi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas