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Effects of salience...
Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder
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- Hamilton, Paul J. (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap (CSAN)
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- Glover, Gary H. (författare)
- Stanford University, CA, USA
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- Bagarinao, Epifanio (författare)
- Stanford University, CA, USA
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- Chang, Catie (författare)
- National Institutes of Health, Bethesda, MD, USA
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- Mackey, Sean (författare)
- Stanford University, CA, USA
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- Sacchet, Matthew D. (författare)
- Stanford University, CA, USA
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- Gotlib, Ian H. (författare)
- Stanford University, CA, USA
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- Engelska.
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Ingår i: Psychiatry Research. - : Elsevier. - 0925-4927 .- 1872-7506. ; 249, s. 91-96
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Neural models of major depressive disorder (MDD) posit that over-response of components of the brains salience network (SN) to negative stimuli plays a crucial role in the pathophysiology of MDD. In the present proof-of-concept study, we tested this formulation directly by examining the affective consequences of training depressed persons to down-regulate response of SN nodes to negative material. Ten participants in the real neurofeedback group saw, and attempted to learn to down-regulate, activity from an empirically identified node of the SN. Ten other participants engaged in an equivalent procedure with the exception that they saw SN-node neurofeedback indices from participants in the real neurofeedback group. Before and after scanning, all participants completed tasks assessing emotional responses to negative scenes and to negative and positive self-descriptive adjectives. Compared to participants in the sham-neurofeedback group, from pre- to post-training, participants in the realneurofeedback group showed a greater decrease in SN-node response to negative stimuli, a greater decrease in self-reported emotional response to negative scenes, and a greater decrease in self-reported emotional response to negative self-descriptive adjectives. Our findings provide support for a neural formulation in which the SN plays a primary role in contributing to negative cognitive biases in MDD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Major depressive disorder; Neurofeedback; Functional magnetic resonance imaging; Salience network; Information processing biases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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