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Post-transcriptiona...
Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation
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- Koch, Stefan (författare)
- Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany
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- Acebron, Sergio P. (författare)
- Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany
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- Herbst, Jessica (författare)
- Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany
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- Hatiboglu, Gencay (författare)
- Department of Urology, University of Heidelberg, Heidelberg, Germany
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- Niehrs, Christof (författare)
- Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany; Institute of Molecular Biology (IMB), Mainz, Germany
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(creator_code:org_t)
- Cambridge, United States : Cell Press, 2015
- 2015
- Engelska.
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Ingår i: Cell. - Cambridge, United States : Cell Press. - 0092-8674 .- 1097-4172. ; 163:5, s. 1225-1236
- Relaterad länk:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The canonical Wnt signaling pathway is of paramount importance in development and disease. An emergent question is whether the upstream cascade of the canonical Wnt pathway has physiologically relevant roles beyond beta-catenin-mediated transcription, which is difficult to study due to the pervasive role of this protein. Here, we show that transcriptionally silent spermatozoa respond to Wnt signals released from the epididymis and that mice mutant for the Wnt regulator Cyclin Y-like 1 are male sterile due to immotile and malformed spermatozoa. Post-transcriptional Wnt signaling impacts spermatozoa through GSK3 by (1) reducing global protein poly-ubiquitination to maintain protein homeostasis; (2) inhibiting septin 4 phosphorylation to establish a membrane diffusion barrier in the sperm tail; and (3) inhibiting protein phosphatase 1 to initiate sperm motility. The results indicate that Wnt signaling orchestrates a rich post-transcriptional sperm maturation program and invite revisiting transcription-independent Wnt signaling in somatic cells as well.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Animals
- Axin Protein/metabolism
- Cyclins/metabolism
- Epididymis/*metabolism
- *Gene Expression Regulation
- Glycogen Synthase Kinase 3/metabolism
- Male
- Mice
- Phosphorylation
- Protein Processing
- Post-Translational
- RNA Processing
- Post-Transcriptional
- Septins/metabolism
- *Sperm Maturation
- *Wnt Signaling Pathway
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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