Sökning: id:"swepub:oai:DiVA.org:liu-175262" >
Prognostic Value of...
Prognostic Value of Nonischemic Ringlike Left Ventricular Scar in Patients With Apparently Idiopathic Nonsustained Ventricular Arrhythmias
-
- Muser, Daniele (författare)
- Hosp Univ Penn, PA 19104 USA; Udine Civil Hosp, Italy
-
- Nucifora, Gaetano (författare)
- Manchester Univ Natl Hlth Serv Fdn Trust, England
-
- Pieroni, Maurizio (författare)
- San Donato Hosp, Italy
-
visa fler...
-
- Castro, Simon A. (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Arroyo, Ruben Casado (författare)
- Univ Libre Bruxelles, Belgium
-
- Maeda, Shingo (författare)
- AOI Universal Hosp, Japan; NYU, NY 10003 USA; San Paolo Hosp, Italy
-
- Benhayon, Daniel A. (författare)
- Mem Healthcare Syst, FL USA
-
- Liuba, Ioan (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Hosp Univ Penn, PA 19104 USA
-
- Sadek, Mouhannad (författare)
- Univ Ottawa, Canada
-
- Magnani, Silvia (författare)
- AOI Universal Hosp, Japan; NYU, NY 10003 USA; San Paolo Hosp, Italy
-
- Enriquez, Andres (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Liang, Jackson J. (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Sassone, Biagio (författare)
- Univ Ferrara, Italy
-
- Desjardins, Benoit (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Dixit, Sanjay (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Deo, Rajat (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Garcia, Fermin C. (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Callans, David J. (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Frankel, David S. (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Selvanayagam, Joseph B. (författare)
- Flinders Univ S Australia, Australia
-
- Marchlinsk, Francis E. (författare)
- Hosp Univ Penn, PA 19104 USA
-
- Santangeli, Pasquale (författare)
- Hosp Univ Penn, PA 19104 USA
-
visa färre...
-
(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2021
- 2021
- Engelska.
-
Ingår i: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 143:14, s. 1359-1373
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Left ventricular (LV) scar on late gadolinium enhancement (LGE) cardiac magnetic resonance has been correlated with life-threatening arrhythmic events in patients with apparently idiopathic ventricular arrhythmias (VAs). We investigated the prognostic significance of a specific LV-LGE phenotype characterized by a ringlike pattern of fibrosis. Methods: A total of 686 patients with apparently idiopathic nonsustained VA underwent contrast-enhanced cardiac magnetic resonance. A ringlike pattern of LV scar was defined as LV subepicardial/midmyocardial LGE involving at least 3 contiguous segments in the same short-axis slice. The end point of the study was time to the composite outcome of all-cause death, resuscitated cardiac arrest because of ventricular fibrillation or hemodynamically unstable ventricular tachycardia and appropriate implantable cardioverter defibrillator therapy. Results: A total of 28 patients (4%) had a ringlike pattern of scar (group A), 78 (11%) had a non-ringlike pattern (group B), and 580 (85%) had normal cardiac magnetic resonance with no LGE (group C). Group A patients were younger compared with groups B and C (median age, 40 vs 52 vs 45 years; P<0.01), more frequently men (96% vs 82% vs 55%; P<0.01), with a higher prevalence of family history of sudden cardiac death or cardiomyopathy (39% vs 14% vs 6%; P<0.01) and more frequent history of unexplained syncope (18% vs 9% vs 3%; P<0.01). All patients in group A showed VA with a right bundle-branch block morphology versus 69% in group B and 21% in group C (P<0.01). Multifocal VAs were observed in 46% of group A patients compared with 26% of group B and 4% of group C (P<0.01). After a median follow-up of 61 months (range, 34-84 months), the composite outcome occurred in 14 patients (50.0%) in group A versus 15 (19.0%) in group B and 2 (0.3%) in group C (P<0.01). After multivariable adjustment, the presence of LGE with ringlike pattern remained independently associated with increased risk of the composite end point (hazard ratio, 68.98 [95% CI, 14.67-324.39], P<0.01). Conclusions: In patients with apparently idiopathic nonsustained VA, nonischemic LV scar with a ringlike pattern is associated with malignant arrhythmic events.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- arrhythmias; cardiac gadolinium; magnetic resonance angiography; prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Muser, Daniele
-
Nucifora, Gaetan ...
-
Pieroni, Maurizi ...
-
Castro, Simon A.
-
Arroyo, Ruben Ca ...
-
Maeda, Shingo
-
visa fler...
-
Benhayon, Daniel ...
-
Liuba, Ioan
-
Sadek, Mouhannad
-
Magnani, Silvia
-
Enriquez, Andres
-
Liang, Jackson J ...
-
Sassone, Biagio
-
Desjardins, Beno ...
-
Dixit, Sanjay
-
Deo, Rajat
-
Garcia, Fermin C ...
-
Callans, David J ...
-
Frankel, David S ...
-
Selvanayagam, Jo ...
-
Marchlinsk, Fran ...
-
Santangeli, Pasq ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Circulation
- Av lärosätet
-
Linköpings universitet