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Mycobacterium tuber...
Mycobacterium tuberculosis-induced apoptotic neutrophils trigger a pro-inflammatory response in macrophages through release of heat shock protein 72, acting in synergy with the bacteria
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- Persson, Alexander, 1978- (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Blomgran-Julinder, Robert (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Rahman, Sayma (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Zheng, Limin (författare)
- Department of Biochemistry, College of Life Sciences, Sun Yansen (Zhongshan) University, Guangzhou, People's Republic of China
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- Stendahl, Olle (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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(creator_code:org_t)
- elsevier, 2008
- 2008
- Engelska.
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Ingår i: Microbes and infection. - : elsevier. - 1286-4579 .- 1769-714X. ; 10:3, s. 233-240
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Mycobacterium tuberculosis (Mtb) survive inside macrophages by manipulating microbicidal functions such as phago-lysosome fusion, production of reactive oxygen species and nitric oxide, and by rendering macrophages non-responsive to IFN-γ. Mtb-infected lung tissue does however not only contain macrophages, but also significant numbers of infiltrating polymorphonuclear neutrophils (PMN). These are able to phagocytose and kill ingested Mtb, but are short-lived cells that constantly need to be removed from tissues to avoid tissue damage. Phagocytosis of aged or UV-induced apoptotic PMN by macrophages induce an anti-inflammatory response in macrophages. However, in the present study, we show that engulfment of Mtb-induced apoptotic PMN by macrophages initiates secretion of TNF-α from the macrophages, reflecting a pro-inflammatory response. Moreover, Mtb-induced apoptotic PMN up-regulate heat shock proteins 60 and 72 (Hsp60, Hsp72) intracellularly and also release Hsp72 extracellularly. We found that both recombinant Hsp72 and released Hsp72 enhanced the pro-inflammatory response to both Mtb-induced apoptotic PMN and Mtb. This stimulatory effect of the supernatant was abrogated by depleting the Hsp72 with immunoprecipitation. These findings indicate that released Hsp72 from Mtb-infected PMN can trigger macrophage activation during the early stage of Mtb infections, thereby creating a link between innate and adaptive immunity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- innate immunity; phagocytes; micobiology
- Microbiology, immunology, infectious diseases
- Mikrobiologi, immunologi, infektionssjukdomar
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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