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γ-Cyclodextrin-BSA ...
γ-Cyclodextrin-BSA for nano-encapsulation of hydrophobic substance
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- Hedi, Wen (författare)
- Jilin Univ, China
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- Jingbo, Liu (författare)
- Jilin Univ, China
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- Yiding, Yu (författare)
- Jilin Univ, China
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- Yuxi, Sun (författare)
- Jilin Univ, China
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- Liu, Jiyun (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Hållbar hälsa
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- Qinqin, Deng (författare)
- Jilin Univ, China
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- Yan, Chen (författare)
- Jilin Univ, China
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- Boqun, Liu (författare)
- Jilin Univ, China
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- Ting, Zhang (författare)
- Jilin Univ, China
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Food Bioscience. - : Elsevier. - 2212-4292 .- 2212-4306. ; 41
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Self-aggregation and the hemolytic effect limit the application of gamma-cyclodextrin (gamma-CD) in bioactive molecular delivery systems. In this study, gamma-CD was modified by grafting onto bovine serum albumin protein (BSA), with epichlorohydrin (ECH) acting as the cross-linking agent. The effects of BSA concentration, reaction temperature, pH and time on the grafting rate were studied, and the gamma-CD-BSA complex with a grafting rate of 99.5 +/- 0.1% +/- 0.06)% was achieved. The complex was confirmed using H-1 NMR and FT-IR spectra. Compared with gamma-CD, the hemolytic effect and self-aggregation of gamma-CD-BSA were significantly reduced, and the encapsulation efficiency of curcumin was increased by 10.8%. The results of scanning electron microscopy showed that both gamma-CD and gamma-CDBSA nanoparticles were formed and the structure of the gamma-CD-BSA complex was more uniform. The pH stability and salt stability of gamma-CD-BSA were higher than gamma-CD. The release rate of gamma-CD-BSA was 15.2 +/- 0.2% after 2 h at pH 1.2, and 57 +/- 1% after 4 h at pH 7.2. The gamma-CD-BSA nanoparticles could protect curcumin in acidic environments and release it in neutral environments. The results suggested a promising wall material for delivery of hydrophobic substances.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- gamma-Cyclodextrin
- Bovine serum albumin
- Hemolysis
- Nano-encapsulation
- Biokemi
- Biochemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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