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Neuroglobin and cyt...
Neuroglobin and cytoglobin as potential enzyme or substrate
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- Trandafir, F. (författare)
- Department of Physics and Biomedical Sciences of the University of Antwerp, Antwerp, Belgium
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- Hoogenwijs, D. (författare)
- Department of Biology, University of Ghent
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- Altieri, F. (författare)
- Department of Biomedical Sciences, University of Rome
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- Rivetti di Val Cervo, P. (författare)
- Department of Biomedical Sciences, University of Rome
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- Ramser, Kerstin (författare)
- Luleå tekniska universitet,Signaler och system
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- Van Doorslaer, S. (författare)
- Department of Physics and Biomedical Sciences of the University of Antwerp, Antwerp, Belgium
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- Vanfleteren, J.R. (författare)
- Department of Biology, University of Ghent
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- Moens, L. (författare)
- Department of Physics and Biomedical Sciences of the University of Antwerp, Antwerp, Belgium
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- Dewilde, Sylvia (författare)
- Department of Physics and Biomedical Sciences of the University of Antwerp, Antwerp, Belgium
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Gene. - : Elsevier BV. - 0378-1119 .- 1879-0038. ; 398:1-2, s. 103-113
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The possible enzymatic activities of neuro- and cytoglobin as well as their potential function as substrates in enzymatic reactions were studied. Neuro- and cytoglobin are found to show no appreciable superoxide dismutase, catalase, and peroxidase activities. However, the internal disulfide bond (CD7-D5) of human neuroglobin can be reduced by thioredoxin reductase. Furthermore, our in vivo and in vitro studies show that Escherichia coli cells contain an enzymatic reducing system that keeps the heme iron atom of neuroglobin in the Fe2+ form in the presence of dioxygen despite the high autoxidation rate of the molecule. This reducing system needs a low-molecular-weight compound as co-factor. In vitro tests show that both NADH and NADPH can play this role. Furthermore, the reducing system is not specific for neuroglobin but allows the reduction of the ferric forms of other globins such as cytoglobin and myoglobin. A similar reducing system is present in eukaryotic tissue protein extracts.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
Nyckelord
- Medical Engineering for Healthcare
- Medicinsk teknik för hälsovård
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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