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Clinical outcome an...
Clinical outcome and time trends of surgically treated renal cell carcinoma between 1986 and 2010 : results from a single centre in Sweden
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- Grabowska, Beata (författare)
- Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Ulvskog, Emma, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Oncology, University Hospital Örebro, Örebro, Sweden
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- Carlsson, Jessica, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
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- Fiorentino, Michelangelo (författare)
- Department of Pathology, F. Addari Institute of Oncology, S. Orsola Hospital, Bologna, Italy
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- Giunchi, Francesca (författare)
- Department of Pathology, F. Addari Institute of Oncology, S. Orsola Hospital, Bologna, Italy
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- Lindblad, Per, 1953- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology
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- Sundqvist, Pernilla, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology
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(creator_code:org_t)
- 2018-07-04
- 2018
- Engelska.
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Ingår i: Scandinavian journal of urology. - : Taylor & Francis Group. - 2168-1805 .- 2168-1813. ; 52:3, s. 206-212
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The aims of this study were to create a cohort of retrospectively collected renal cell carcinoma (RCC) specimens to be used a basis for prognostic molecular studies, and to investigate the outcome and time trends in patients surgically treated for RCC in a single-centre cohort.MATERIALS AND METHODS: Patients undergoing surgery for RCC between 1986 and 2010 were included in the study. Medical records were reviewed, and the diagnostic tissue was re-evaluated according to a modern classification. The change in patient and tumour characteristics over time was analysed.RESULTS: The study included 345 patients. Smaller tumours, as indicated by primary tumour diameter, tumour (T) stage and American Joint Committee on Cancer (AJCC) stage, were found more frequently in later years compared to the early 1990s. No changes in the clinical outcome for the patients were seen among the time periods investigated. Increasing T stage, AJCC stage, primary tumour diameter and decreasing haemoglobin levels were associated with cancer-specific mortality in univariate analysis. A high calcium level was significantly associated with increased cancer-specific mortality (hazard ratio = 4.25, 95% confidence interval 1.36-13.28) in multivariate analysis.CONCLUSIONS: This study on patients who underwent surgery for RCC from 1986 to 2010 at a single institution in Sweden indicates that there has been a change in tumour characteristics of patients diagnosed with RCC over time. It was also shown that calcium levels were an independent prognostic factor for cancer-specific mortality in this cohort. This cohort could provide a valuable basis for further molecular studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- OKCC
- RCC
- histopathology
- kidney cancer
- molecular biomarkers
- renal cancer
- survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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