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Lipidomic and Metab...
Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity
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- Lanzon, Borja (author)
- LIPOBETA Group, Department Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Alcorcón, Spain
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- Martin-Taboada, Marina (author)
- LIPOBETA Group, Department Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Alcorcón, Spain
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- Castro Alves, Victor, 1986- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Vila-Bedmar, Rocio (author)
- LIPOBETA Group, Department Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Alcorcón, Spain
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- González de Pablos, Ignacio (author)
- Department of Nephrology, University Hospital 12 de Octubre, Madrid, Spain
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- Duberg, Daniel, 1985- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Gomez, Pilar (author)
- Department of Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain
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- Rodriguez, Elias (author)
- Department of Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Morales, Enrique (author)
- Department of Nephrology, University Hospital 12 de Octubre, Madrid, Spain; Research Institute of University Hospital 12 de Octubre (imas12), Madrid, Spain; Department of Medicine, Complutense University of Madrid, Madrid, Spain
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- Ruperez, Francisco J. (author)
- Centro de Metabolómica y Bioanálisis (CEMBIO), Universidad San Pablo-CEU, CEU Universities, Boadilla del Monte, Spain
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- Medina-Gomez, Gema (author)
- LIPOBETA Group, Department Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Alcorcón, Spain; LAFEMEX Laboratory, Área de Bioquímica y Biología Molecular, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Spain
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(creator_code:org_t)
- 2021-12-03
- 2021
- English.
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In: Metabolites. - : MDPI. - 2218-1989 .- 2218-1989. ; 11:12
- Related links:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Severe obesity is a major risk for chronic kidney disease (CKD). Early detection and careful monitoring of renal function are critical for the prevention of CKD during obesity, since biopsies are not performed in patients with CKD and diagnosis is dependent on the assessment of clinical parameters. To explore whether distinct lipid and metabolic signatures in obesity may signify early stages of pathogenesis toward CKD, liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-high resolution accurate mass-mass spectrometry (GC-HRAM-MS) analyses were performed in the serum and the urine of severely obese patients with and without CKD. Moreover, the impact of bariatric surgery (BS) in lipid and metabolic signature was also studied, through LC-MS and GC-HRAM-MS analyses in the serum and urine of patients with severe obesity and CKD before and after undergoing BS. Regarding patients with severe obesity and CKD compared to severely obese patients without CKD, serum lipidome analysis revealed significant differences in lipid signature. Furthermore, serum metabolomics profile revealed significant changes in specific amino acids, with isoleucine and tyrosine, increased in CKD patients compared with patients without CKD. LC-MS and GC-HRAM-MS analysis in serum of patients with severe obesity and CKD after BS showed downregulation of levels of triglycerides (TGs) and diglycerides (DGs) as well as a decrease in branched-chain amino acid (BCAA), lysine, threonine, proline, and serine. In addition, BS removed most of the correlations in CKD patients against biochemical parameters related to kidney dysfunction. Concerning urine analysis, hippuric acid, valine and glutamine were significantly decreased in urine from CKD patients after surgery. Interestingly, bariatric surgery did not restore all the lipid species, some of them decreased, hence drawing attention to them as potential targets for early diagnosis or therapeutic intervention. Results obtained in this study would justify the use of comprehensive mass spectrometry-based lipidomics to measure other lipids aside from conventional lipid profiles and to validate possible early markers of risk of CKD in patients with severe obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- CKD
- bariatric surgery
- lipidomics
- metabolomics
- severe obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lanzon, Borja
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Martin-Taboada, ...
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Castro Alves, Vi ...
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Vila-Bedmar, Roc ...
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González de Pabl ...
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Duberg, Daniel, ...
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Gomez, Pilar
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Rodriguez, Elias
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Oresic, Matej, 1 ...
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Hyötyläinen, Tuu ...
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Morales, Enrique
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Ruperez, Francis ...
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Medina-Gomez, Ge ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Metabolites
- By the university
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Örebro University