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Synthesis and chara...
Synthesis and characterization of surface-active compounds derived from cholesterol derivatives and glucose
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Piispanen, PS (författare)
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Byström, S (författare)
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Svensson, M (författare)
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visa fler...
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- Kronberg, B (författare)
- RISE,YKI – Ytkemiska institutet
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Blute, I (författare)
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Norin, T (författare)
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visa färre...
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Journal of Surfactants and Detergents (JSD). - 1097-3958 .- 1558-9293. ; 5, s. 345-351
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The synthesis and characterization of surface-active compounds based on various steroid derivatives and glucose are presented. The hydrophobic and hydrophilic parts of the compounds were linked via glucosidic bonds. All compounds were found to have very low water solubility and only limited solubility in various organic solvents. The compounds were investigated according to their ability to interact with an anionic surfactant, sodium dodecylsulfate (SDS), in order to induce a decrease in the critical micelle concentration (CMC) of the surfactants. This synergistic effect was pronounced for cholestanol-6-on-ß-d-glucopyranoside and for cholestan-3,6-diol-ß-d-glucopyranoside. These two compounds lowered the CMC from 8 to 6 and 0.6 mM, respectively, for water solutions of SDS/glucoside with a molar ratio of 92:8. Furthermore, the ability of the compounds to stabilize lipid membranes, in liposomes, at varying concentrations of Ca2+, was studied. The compounds were, as expected, found to induce stabilization similar to that of cholesterol
Nyckelord
- Cholesterol derivatives
- surfactants
- glucoside
- liposome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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