Sökning: id:"swepub:oai:DiVA.org:su-156412" >
Estimation of Risk ...
Estimation of Risk of Normal-tissue Toxicity Following Gastric Cancer Radiotherapy with Photon- or Scanned Proton-beams
-
- Mondlane, Gracinda, 1987- (författare)
- Stockholms universitet,Fysikum,Eduardo Mondlane University, Mozambique
-
- Ureba, Ana (författare)
- Karolinska Institutet,Stockholms universitet,Fysikum
-
- Gubanski, Michael (författare)
- Karolinska Institutet
-
visa fler...
-
- Lind, Pehr A. (författare)
- Karolinska Institutet
-
- Siegbahn, Albert (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Anticancer Research USA Inc. 2018
- 2018
- Engelska.
-
Ingår i: Anticancer Research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 38:5, s. 2619-2625
- Relaterad länk:
-
https://doi.org/10.2...
-
visa fler...
-
http://ar.iiarjourna...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background/Aim: Gastric cancer (GC) radiotherapy involves irradiation of large tumour volumes located in the proximities of critical structures. The advantageous dose distributions produced by scanned-proton beams could reduce the irradiated volumes of the organs at risk (OARs). However, treatment-induced side-effects may still appear. The aim of this study was to estimate the normal tissue complication probability (NTCP) following proton therapy of GC, compared to photon radiotherapy. Patients and Methods: Eight GC patients, previously treated with volumetric-modulated arc therapy (VMAT), were retrospectively planned with scanned proton beams carried out with the single-field uniform-dose (SFUD) method. A beam-specific planning target volume was used for spot positioning and a clinical target volume (CTV) based robust optimisation was performed considering setup- and range-uncertainties. The dosimetric and NTCP values obtained with the VMAT and SFUD plans were compared. Results: With SFUD, lower or similar dose-volume values were obtained for OARs, compared to VMAT. NTCP values of 0% were determined with the VMAT and SFUD plans for all OARs (p>0.05), except for the left kidney (p<0.05), for which lower toxicity was estimated with SFUD. Conclusion: The NTCP reduction, determined for the left kidney with SFUD, can be of clinical relevance for preserving renal function after radiotherapy of GC.
Ämnesord
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- NTCP
- gastric cancer
- VMAT
- SFUD
- treatment planning
- Medical Radiation Physics
- medicinsk strålningsfysik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas