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High lifelong cogni...
High lifelong cognitive reserve prolongs disability-free survival : The role of cognitive function
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Li, Xuerui (author)
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Yang, Wenzhe (author)
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Wang, Jiao (author)
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- Dove, Abigail (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Qi, Xiuying (author)
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Bennett, David A. (author)
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- Xu, Weili (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, China; Center for International Collaborative Research on Environment, Nutrition and Public Health, China
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(creator_code:org_t)
- 2022-03-28
- 2023
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:1, s. 208-216
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Introduction: The association between cognitive reserve (CR) and survival with independence is unknown. We examined whether lifelong CR accumulation is associated with disability-free survival and explored the extent to which cognitive function mediates this association.Methods: Within the Rush Memory and Aging Project, 1633 dementia- and disability-free participants were followed annually for up to 22 years. Lifelong CR including education, early-/mid-/late-life cognitive activities, and late-life social activity was assessed and tertiled.Results: CR score was dose-dependently associated with disability/death (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.93–0.99). Compared to low CR, the HR (95% CI) of disability/death was 0.82 (0.70–0.95) for high CR. The median disability-free survival time was prolonged by 0.99 (95% CI 0.28–1.71) years for participants with high CR. Cognitive function mediated 35.7% of the association between CR and disability-free survival.Discussion: High lifelong CR was associated with prolonged disability-free survival. Cognitive function mediates about one-third of this association. Our findings underscore the importance of CR for healthy aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- cognitive function
- cognitive reserve
- community-based cohort study
- disability
- survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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