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Modular gene expres...
Modular gene expression in Poplar : a multilayer network approach
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- Grönlund, Andreas (författare)
- Umeå universitet,Institutionen för fysiologisk botanik,Umeå Plant Science Center Department of Forest Genetics and Plant Physiology, University of Agricultural Sciences, Umeå, Sweden
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- Bhalerao, Rishikesh P. (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Umeå universitet,Umeå Plant Science Centre (UPSC),Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology
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- Karlsson, Jan (författare)
- Umeå universitet,Institutionen för fysiologisk botanik,Umeå Plant Science Centre (UPSC)
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(creator_code:org_t)
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- 2008-12-16
- 2009
- Engelska.
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Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 181:2, s. 315-322
- Relaterad länk:
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http://www.ncbi.nlm....
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https://nph.onlineli...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- * By applying a multilayer network approach to an extensive set of Poplar microarray data, a genome-wide coexpression network has been detected and explored. * Multilayer networks were generated from minimum spanning trees (MSTs) using Kruskal's algorithm from random jack-knife resamplings of half of the full data set. The final network is obtained from the union of all the generated MSTs. * The gene expression correlations display a highly clustered topology, which is more pronounced when introducing links appearing in relatively few of the generated MSTs. The network also reveals a modular architecture, reflecting functional groups with relatively frequent gene-to-gene communication. Furthermore, the observed modular structure overlaps with different gene activities in different tissues, and closely related tissues show similar over- and/or under-expression patterns at the modular scale. * It is shown that including links that appear in a few of the generated MSTs increases the information quality of the network. In other words, a link may be 'weak' because it reflects rare signaling events rather than merely a signal weakened by noise. The method allows, from comparisons of random 'null networks', tuning to maximize the information obtainable.
Ämnesord
- NATURVETENSKAP -- Biologi -- Botanik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Botany (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Skogsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Forest Science (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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