Sökning: id:"swepub:oai:DiVA.org:umu-133666" >
Gilles de la Touret...
Gilles de la Tourette syndrome
-
Robertson, Mary M. (författare)
-
Eapen, Valsamma (författare)
-
Singer, Harvey S. (författare)
-
visa fler...
-
Martino, Davide (författare)
-
Scharf, Jeremiah M. (författare)
-
Paschou, Peristera (författare)
-
Roessner, Veit (författare)
-
Woods, Douglas W. (författare)
-
- Hariz, Marwan (författare)
- Umeå universitet,Klinisk neurovetenskap,Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK
-
Mathews, Carol A. (författare)
-
Crncec, Rudi (författare)
-
Leckman, James F. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2017-02-02
- 2017
- Engelska.
-
Ingår i: Nature reviews disease primers. - United Kingdom : Nature Publishing Group. - 2056-676X. ; 3
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder that is characterized by several motor and phonic tics. Tics usually develop before 10 years of age, exhibit a waxing and waning course and typically improve with increasing age. A prevalence of approximately 1% is estimated in children and adolescents. The condition can result in considerable social stigma and poor quality of life, especially when tics are severe (for example, with coprolalia (swearing tics) and self-injurious behaviours) or when GTS is accompanied by attention-deficit/hyperactivity disorder, obsessive-compulsive disorder or another neuropsychiatric disorder. The aetiology is complex and multifactorial. GTS is considered to be polygenic, involving multiple common risk variants combined with rare, inherited or de novo mutations. These as well as non-genetic factors (such as perinatal events and immunological factors) are likely to contribute to the heterogeneity of the clinical phenotype, the structural and functional brain anomalies and the neural circuitry involvement. Management usually includes psychoeducation and reassurance, behavioural methods, pharmacotherapy and, rarely, functional neurosurgery. Future research that integrates clinical and neurobiological data, including neuroimaging and genetics, is expected to reveal the pathogenesis of GTS at the neural circuit level, which may lead to targeted interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Robertson, Mary ...
-
Eapen, Valsamma
-
Singer, Harvey S ...
-
Martino, Davide
-
Scharf, Jeremiah ...
-
Paschou, Periste ...
-
visa fler...
-
Roessner, Veit
-
Woods, Douglas W ...
-
Hariz, Marwan
-
Mathews, Carol A ...
-
Crncec, Rudi
-
Leckman, James F ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Nature reviews d ...
- Av lärosätet
-
Umeå universitet