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Fucose binding moti...
Fucose binding motifs on mucin core glycopeptides impact bacterial lectin recognition
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- Behren, Sandra (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany
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- Yu, Jin (författare)
- Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany; Glycosciences Laboratory, Imperial College London, London, United Kingdom
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- Pett, Christian (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany
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- Schorlemer, Manuel (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany
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- Heine, Viktoria (författare)
- Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany
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- Fischöder, Thomas (författare)
- Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany
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- Elling, Lothar (författare)
- Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany
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- Westerlind, Ulrika (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Angewandte Chemie International Edition. - 1433-7851 .- 1521-3773. ; 62:32
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mucin glycoproteins are essential components of the mucosal barrier, which protects the host from pathogens. Throughout evolution, bacteria have developed strategies to modulate and penetrate this barrier, and cause virulence by interacting with mucin O-glycans at the epithelial cell-surface. O-fucosylated glycan epitopes on mucins are key ligands of many bacterial lectins. Here, a chemoenzymatic synthesis strategy is described to prepare a library of fucosylated mucin core glycopeptides to enable studies of mucin-interacting and fucose-binding bacterial lectins. Glycan cores with biologically important Lewis and H-antigens were prepared decorating the peptide backbone at different sites and densities. The fucosylated mucin glycopeptides were applied in microarray binding studies to explore the importance of glycan core and peptide backbone presentation of these antigens in binding interactions with the P. aeruginosa lectin LecB and the C. difficile toxin A.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Fucose
- Glycopeptides
- Glycosylation
- Lectins
- Microarrays
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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