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The [PSI+] prion mo...
The [PSI+] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12
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- Saini, Pawan Kumar (författare)
- Université Grenoble-Alpes, Grenoble, France
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- Dawitz, Hannah (författare)
- Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
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- Kohler, Andreas, Dr. rer. nat. 1988- (författare)
- Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
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- Bondarev, Stanislav (författare)
- Department of Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia
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- Thomas, Jinsu (författare)
- Université Grenoble-Alpes, Grenoble, France
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- Amblard, Amélie (författare)
- Université Grenoble-Alpes, Grenoble, France
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- Stewart, James (författare)
- Max Planck Institute for Biology of Ageing, Cologne, Germany; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
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- Thierry-Mieg, Nicolas (författare)
- Université Grenoble-Alpes, Grenoble, France
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- Ott, Martin (författare)
- Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden
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- Pierrel, Fabien (författare)
- Université Grenoble-Alpes, Grenoble, France
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(creator_code:org_t)
- American Society for Cell Biology (ASCB), 2022
- 2022
- Engelska.
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Ingår i: Molecular Biology of the Cell. - : American Society for Cell Biology (ASCB). - 1059-1524 .- 1939-4586. ; 33:14
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cytochrome c oxidase (CcO) is a pivotal enzyme of the mitochondrial respiratory chain, which sustains bioenergetics of eukaryotic cells. Cox12, a peripheral subunit of CcO oxidase, is required for full activity of the enzyme, but its exact function is unknown. Here experimental evolution of a Saccharomyces cerevisiae Δcox12 strain for ∼300 generations allowed to restore the activity of CcO oxidase. In one population, the enhanced bioenergetics was caused by a A375V mutation in the cytosolic AAA+ disaggregase Hsp104. Deletion or overexpression of HSP104 also increased respiration of the Δcox12 ancestor strain. This beneficial effect of Hsp104 was related to the loss of the [PSI+] prion, which forms cytosolic amyloid aggregates of the Sup35 protein. Overall, our data demonstrate that cytosolic aggregation of a prion impairs the mitochondrial metabolism of cells defective for Cox12. These findings identify a new functional connection between cytosolic proteostasis and biogenesis of the mitochondrial respiratory chain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Saini, Pawan Kum ...
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Dawitz, Hannah
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Kohler, Andreas, ...
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Bondarev, Stanis ...
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Thomas, Jinsu
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Amblard, Amélie
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visa fler...
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Stewart, James
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Thierry-Mieg, Ni ...
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Ott, Martin
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Pierrel, Fabien
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- MEDICIN OCH HÄLSOVETENSKAP
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