Sökning: id:"swepub:oai:DiVA.org:umu-48993" >
Longitudinal analys...
Longitudinal analysis of the human T cell response during acute hantavirus infection
-
- Lindgren, Therese, 1977- (författare)
- Clas Ahlm
-
- Ahlm, Clas, 1956- (författare)
- Umeå universitet,Infektionssjukdomar,Clas Ahlm ; Arcum
-
- Mohamed, Nahla, 1978- (författare)
- Umeå universitet,Infektionssjukdomar,Virologi,Ahlm o Evander
-
visa fler...
-
- Evander, Magnus, 1959- (författare)
- Umeå universitet,Virologi,Magnus Evander ; Arcum
-
- Ljunggren, Hans-Gustaf (författare)
- Karolinska Institutet
-
- Björkström, Niklas K (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Baltimore : American Society for Microbiology, 2011
- 2011
- Engelska.
-
Ingår i: Journal of Virology. - Baltimore : American Society for Microbiology. - 0022-538X .- 1098-5514. ; 85:19, s. 10252-10260
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Longitudinal studies of T cell immune responses during viral infections in humans are essential for our understanding of how effector T cell responses develop, clear infection, and provide long-lasting immunity. Here, following an outbreak of a Puumala hantavirus infection in the human population, we longitudinally analyzed the primary CD8 T cell response in infected individuals from the first onset of clinical symptoms until viral clearance. A vigorous CD8 T cell response was observed early following the onset of clinical symptoms, determined by the presence of high numbers of Ki67(+)CD38(+)HLA-DR(+) effector CD8 T cells. This response encompassed up to 50% of total blood CD8 T cells, and it subsequently contracted in parallel with a decrease in viral load. Expression levels of perforin and granzyme B were high throughout the initial T cell response and likewise normalized following viral clearance. When monitoring regulatory components, no induction of regulatory CD4 or CD8 T cells was observed in the patients during the infection. However, CD8 as well as CD4 T cells exhibited a distinct expression profile of inhibitory PD-1 and CTLA-4 molecules. The present results provide insight into the development of the T cell response in humans, from the very onset of clinical symptoms following a viral infection to resolution of the disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas