Sökning: id:"swepub:oai:DiVA.org:umu-49369" >
Allopregnanolone, a...
Allopregnanolone, a GABA-A receptor agonist, decreases gonadotropin levels in women : a preliminary study
-
- Timby, Erika, 1974- (författare)
- Umeå universitet,Obstetrik och gynekologi,Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden
-
- Hedström, Helena (författare)
- Umeå universitet,Obstetrik och gynekologi,Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden
-
- Bäckström, Torbjörn (författare)
- Umeå universitet,Obstetrik och gynekologi,Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden
-
visa fler...
-
- Sundström-Poromaa, Inger (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
-
- Nyberg, Sigrid (författare)
- Umeå universitet,Obstetrik och gynekologi,Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden
-
- Bixo, Marie (författare)
- Umeå universitet,Obstetrik och gynekologi,Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2010-12-29
- 2011
- Engelska.
-
Ingår i: Gynecological Endocrinology. - : Informa Healthcare. - 0951-3590 .- 1473-0766. ; 27:12, s. 1087-1093
- Relaterad länk:
-
https://umu.diva-por... (primary) (Raw object)
-
visa fler...
-
http://umu.diva-port...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Animal studies suggest regulatory effects on the hypothalamic-pituitary-gonad axis by allopregnanolone, an endogenous gamma-aminobutyric acid A (GABAA) receptor agonist. Elevated levels of allopregnanolone in women with hypothalamic amenorrhea have been seen. Isoallopregnanolone is an isomer to allopregnanolone, but without GABAA receptor effects. The purpose of this study was to investigate effects of allopregnanolone and isoallopregnanolone on gonadotropin levels in healthy women of fertile age. Ten women were given allopregnanolone and five women isoallopregnanolone intravenously in follicular phase. Repeated blood samples were drawn during the test day. Main outcomes were changes in serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, and progesterone. Serum-FSH decreased between 5 and 105 min after the allopregnanolone injection (F(16,144)=2.18, p=0.008). Serum-LH was reduced between 5 and 35 min following the allopregnanolone injection (F(16,144)=2.63, p=0.001). Serum-oestradiol and -progesterone were not significantly changed after allopregnanolone injections. No effect on gonadotropin levels were seen after administration of isoallopregnanolone. Allopregnanolone reduces FSH and LH levels in women and the effect might be mediated via a specific GABAA receptor activation since isoallopregnanolone lacked this effect. Although the number of women was small, the results suggest a regulatory mechanism on the hypothalamic-pituitary-gonadal axis by allopregnanolon.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- FSH
- LH
- GABA
- allopregnanolone
- isoallopregnanolone
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas