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Epidemiology of Res...
Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection Hospitalizations Among HIV-Infected and HIV-Uninfected South African Children, 2010-2011
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Moyes, Jocelyn (författare)
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Cohen, Cheryl (författare)
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Pretorius, Marthi (författare)
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Groome, Michelle (författare)
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von Gottberg, Anne (författare)
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Wolter, Nicole (författare)
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Walaza, Sibongile (författare)
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Haffejee, Sumayya (författare)
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Chhagan, Meera (författare)
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Naby, Fathima (författare)
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Cohen, Adam L. (författare)
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Tempia, Stefano (författare)
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- Kahn, Kathleen (författare)
- Umeå universitet,Epidemiologi och global hälsa,INDEPTH network, Accra, Ghana
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Dawood, Halima (författare)
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Venter, Marietjie (författare)
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Madhi, Shabir A. (författare)
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(creator_code:org_t)
- 2013-11-21
- 2013
- Engelska.
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 208:Supplement: 3, s. S217-S226
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background. There are limited data on respiratory syncytial virus (RSV) infection among children in settings with a high prevalence of human immunodeficiency virus (HIV). We studied the epidemiology of RSV-associated acute lower respiratory tract infection (ALRTI) hospitalizations among HIV-infected and HIV-uninfected children in South Africa. Methods. Children aged <5 years admitted to sentinel surveillance hospitals with physician-diagnosed neonatal sepsis or ALRTI were enrolled. Nasopharyngeal aspirates were tested by multiplex real-time polymerase chain reaction assays for RSV and other viruses. Associations between possible risk factors and severe outcomes for RSV infection among HIV-infected and uninfected children were examined. The relative risk of hospitalization in HIV-infected and HIV-uninfected children was calculated in 1 site with population denominators. Results. Of 4489 participants, 4293 (96%) were tested for RSV, of whom 1157 (27%) tested positive. With adjustment for age, HIV-infected children had a 3-5-fold increased risk of hospitalization with RSV-associated ALRTI (2010 relative risk, 5.6; [95% confidence interval (CI), 4.5-6.4]; 2011 relative risk, 3.1 [ 95% CI, 2.6-3.6]). On multivariable analysis, HIV-infected children with RSV-associated ALRTI had higher odds of death (adjusted odds ratio. 31.1; 95% CI, 5.4-179.8) and hospitalization for >5 days (adjusted odds ratio, 4.0; 95% CI, 1.5-10.6) than HIV-uninfected children. Conclusion. HIV-infected children have a higher risk of hospitalization with RSV-associated ALRTI and a poorer outcome than HIV-uninfected children. These children should be targeted for interventions aimed at preventing severe RSV disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Moyes, Jocelyn
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Cohen, Cheryl
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Pretorius, Marth ...
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Groome, Michelle
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von Gottberg, An ...
-
Wolter, Nicole
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visa fler...
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Walaza, Sibongil ...
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Haffejee, Sumayy ...
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Chhagan, Meera
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Naby, Fathima
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Cohen, Adam L.
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Tempia, Stefano
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Kahn, Kathleen
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Dawood, Halima
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Venter, Marietji ...
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Madhi, Shabir A.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Journal of Infec ...
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Umeå universitet