Sökning: id:"swepub:oai:DiVA.org:uu-102842"
> (2009) >
Study of functional...
Study of functional variants of the BANK1 gene in rheumatoid arthritis
-
Orozco, Gisela (författare)
-
- Abelson, Anna-Karin (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
González-Gay, Miguel A. (författare)
-
visa fler...
-
Balsa, Alejandro (författare)
-
Pascual-Salcedo, Dora (författare)
-
García, Antonio (författare)
-
Fernández-Gutierrez, Benjamín (författare)
-
- Petersson, Ingemar (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Pons-Estel, Bernardo (författare)
-
Eimon, Alicia (författare)
-
Paira, Sergio (författare)
-
Scherbarth, Hugo R. (författare)
-
- Alarcón-Riquelme, Marta (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
Martín, Javier (författare)
-
visa färre...
-
(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
-
Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 60:2, s. 372-379
- Relaterad länk:
-
https://onlinelibrar...
-
visa fler...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: To investigate 1 functional (rs17266594) and 2 potentially functional (rs10516487 and rs3733197) BANK1 variants, which were previously identified as systemic lupus erythematosus (SLE) susceptibility markers, to test whether they are associated with rheumatoid arthritis (RA). METHODS: Four different cohorts were included in the study: 1,080 RA patients and 1,368 healthy controls from Spain, 278 RA patients and 568 healthy controls from Sweden, 288 RA patients and 287 healthy controls from Argentina, and 288 RA patients and 288 healthy controls from Mexico. Samples were genotyped for BANK1 single-nucleotide polymorphisms (SNPs) using a TaqMan 5'-allele discrimination assay. Statistical analysis comparing allele and genotype distributions was performed with the chi-square test. RESULTS: We did not find a significant association between RA and the rs10516487 and rs17266594 BANK1 polymorphisms. However, there was an increase in the major alleles among RA patients. Similarly, for rs3733197, there was an increase in the major allele among patients in every cohort. Nevertheless, this skewing reached statistical significance in the Spanish (P = 0.01, odds ratio [OR] 1.17 [95% confidence interval (95% CI) 1.03-1.32]) and Argentinean (P = 0.04, OR 1.31 [95% CI 1.00-1.72]) populations. We found a significant association of rs10516487 (P = 0.005, OR 1.15 [95% CI 1.04-1.28]) and rs3733197 (P = 0.0009, OR 1.17 [95% CI 1.07-1.29]) with RA in the pooled analysis. In a 3-SNP haplotype analysis, we found that the major TGG haplotype was significantly associated with RA (P = 0.005, OR 1.14 [95% CI 1.04-1.25]). In addition, we found a common CAA haplotype that was protective against RA (P = 0.0004, OR 0.82 [95% CI 0.74-0.92]). CONCLUSION: These results suggest that BANK1 SNPs and haplotypes may contribute to RA susceptibility with a low risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Orozco, Gisela
-
Abelson, Anna-Ka ...
-
González-Gay, Mi ...
-
Balsa, Alejandro
-
Pascual-Salcedo, ...
-
García, Antonio
-
visa fler...
-
Fernández-Gutier ...
-
Petersson, Ingem ...
-
Pons-Estel, Bern ...
-
Eimon, Alicia
-
Paira, Sergio
-
Scherbarth, Hugo ...
-
Alarcón-Riquelme ...
-
Martín, Javier
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Arthritis and Rh ...
- Av lärosätet
-
Uppsala universitet
-
Lunds universitet