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Multicentre analysi...
Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery
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den Dulk, M. (författare)
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Marijnen, C. A. M. (författare)
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Collette, L. (författare)
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Putter, H. (författare)
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- Påhlman, Lars (författare)
- Uppsala universitet,Kolorektalkirurgi
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- Folkesson, Joakim (författare)
- Uppsala universitet,Kolorektalkirurgi
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Bosset, J-F. (författare)
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Rödel, C. (författare)
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Bujko, K. (författare)
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van de Velde, C. J. H. (författare)
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(creator_code:org_t)
- 2009-08-11
- 2009
- Engelska.
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 96:9, s. 1066-75
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The association between diverting stomas and symptomatic anastomotic leakage after rectal cancer surgery was studied, as well as the impact of leakage on local recurrence, distant metastasis, and disease-free, overall and cancer-specific survival. METHODS: Data from the Swedish Rectal Cancer Trial, Dutch TME trial, CAO/ARO/AIO-94 trial, EORTC 22921 trial and Polish Rectal Cancer Trial were pooled (n = 5187). All eligible patients without distant metastases at the time of low anterior resection were selected (n = 2726); overall survival was studied in patients aged 75 years or less (n = 2480). Multivariable models were used to study the association between diverting stomas and anastomotic leakage, and between leakage and recurrence or survival. RESULTS: Some 9.7 per cent of patients were diagnosed with a symptomatic anastomotic leak; diverting stomas were negatively associated with leakage (11.6 per cent without and 7.8 per cent with a stoma; P = 0.002). Anastomotic leakage was negatively associated with overall survival in the multivariable analysis (hazard ratio (HR) 1.29 (95 per cent confidence interval 1.02 to 1.63); P = 0.034), but not with cancer-specific survival (HR 1.12 (0.83 to 1.52); P = 0.466). CONCLUSION: Diverting stomas were associated with less symptomatic anastomotic leakage. Oncological outcome was not significantly influenced by leakage, but overall survival was reduced.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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den Dulk, M.
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Marijnen, C. A. ...
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Collette, L.
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Putter, H.
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Påhlman, Lars
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Folkesson, Joaki ...
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visa fler...
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Bosset, J-F.
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Rödel, C.
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Bujko, K.
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van de Velde, C. ...
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visa färre...
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British Journal ...
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Uppsala universitet