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Increase of BDNF se...
Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease
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Leyhe, Thomas (författare)
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Eschweiler, Gerhard W (författare)
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Stransky, Elke (författare)
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Gasser, Thomas (författare)
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- Annas, Peter (författare)
- Karolinska Institutet
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- Basun, Hans (författare)
- Uppsala universitet,Geriatrik
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Laske, Christoph (författare)
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 16:3, s. 649-656
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Preclinical and clinical studies gave evidence that lithium could be useful in the treatment of Alzheimer's disease (AD). In experimental investigations, lithium induces brain-derived neurotrophic factor (BDNF). Recent studies have found a decrease of BDNF in the serum and brains of AD patients with potentially consecutive lack of neurotrophic support. We assessed the influence of a lithium treatment on BDNF serum concentration in a subset of a greater sample recruited for a randomized, single-blinded, placebo-controlled, parallel-group multicenter 10-week study, investigating the efficacy of lithium treatment in AD patients. In AD patients treated with lithium, a significant increase of BDNF serum levels, and additionally a significant decrease of ADAS-Cog sum scores in comparison to placebo-treated patients, were found. Diminution of cognitive impairment was inversely correlated with lithium serum concentration. Upregulation of BDNF might be part of a neuroprotective effect of lithium in AD patients. The results of the present investigation encourage performing studies with longer treatment phases to observe potential positive long-term effects of lithium in AD patients.
Nyckelord
- Alzheimer’s disease
- brain-derived neurotrophic factor
- lithium
- neuroprotection
- neurotrophic effect
- placebocontrolled trial
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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