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Cystatin C as a mar...
Cystatin C as a marker of immune complex-associated renal impairment in a sudanese population with visceral leishmaniasis
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ElShafie, Amir Ibrahim (författare)
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Elghazali, Gehad (författare)
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- Rönnelid, Johan (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet
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visa fler...
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- Venge, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Inflammation
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visa färre...
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: American Journal of Tropical Medicine and Hygiene. - 0002-9637 .- 1476-1645. ; 75:5, s. 864-868
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Renal function was studied in visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL) by means of the specific marker cystatin C and related to circulating immune complexes and cytokine production. Forty patients with VL (23 with sub-acute disease and 17 with acute disease), 17 patients with PKDL, and 22 healthy controls were included. Cystatin C, but not creatinine, was significantly raised in VL (P = 0.004). The highest levels of cystatin C were found in those with acute disease (P < 0.0001). In VL, cystatin C levels were positively correlated to circulating immune complexes and production of granulocyte-macrophage colony stimulating factor (GM-CSF), but negatively correlated to aspartate aminotransferase and lactate dehydrogenase. We conclude that cystatin C is a superior marker of glomerular function in leishmaniasis and that immune complex deposition and GM-CSF are two functions that most likely are causally involved in the mechanisms leading to glomerular dysfunction in leishmaniasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Clinical chemistry
- Klinisk kemi
- Clinical immunology
- Klinisk immunologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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