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Direct targeted qua...
Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections
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- Shariatgorji, Mohammadreza (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Nilsson, Anna (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Goodwin, Richard J A (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Källback, Patrik (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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Schintu, Nicoletta (author)
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- Zhang, Xiaoqun (author)
- Karolinska Institutet
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Crossman, Alan R (author)
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Bezard, Erwan (author)
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- Svenningsson, Per (author)
- Karolinska Institutet
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- Andrén, Per E (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Medicinsk masspektrometri
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Neuron. - : Elsevier BV. - 0896-6273 .- 1097-4199. ; 84:4, s. 697-707
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https://urn.kb.se/re...
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Abstract
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- Current neuroimaging techniques have very limited abilities to directly identify and quantify neurotransmitters from brain sections. We have developed a molecular-specific approach for the simultaneous imaging and quantitation of multiple neurotransmitters, precursors, and metabolites, such as tyrosine, tryptamine, tyramine, phenethylamine, dopamine, 3-methoxytyramine, serotonin, GABA, glutamate, acetylcholine, and L-alpha-glycerylphosphorylcholine, in histological tissue sections at high spatial resolutions. The method is employed to directly measure changes in the absolute and relative levels ofneurotransmitters in specific brain structures in animal disease models and in response to drug treatments, demonstrating the power of mass spectrometry imaging in neuroscience.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neuron
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- By the author/editor
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Shariatgorji, Mo ...
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Nilsson, Anna
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Goodwin, Richard ...
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Källback, Patrik
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Schintu, Nicolet ...
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Zhang, Xiaoqun
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show more...
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Crossman, Alan R
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Bezard, Erwan
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Svenningsson, Pe ...
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Andrén, Per E
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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and Medical Bioscien ...
- Articles in the publication
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Neuron
- By the university
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Uppsala University
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Karolinska Institutet