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Free and bound sodi...
Free and bound sodium in pancreatic beta-cells exposed to glucose and tolbutamide.
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Ali, L (author)
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Grapengiesser, E (author)
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Gylfe, E (author)
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Hellman, B (author)
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Lund, P E (author)
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- 1989
- 1989
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 164:1, s. 212-8
- Related links:
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https://urn.kb.se/re...
Abstract
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- The effects of glucose and tolbutamide on the sodium handling of the pancreatic beta-cells were evaluated by measuring the total sodium content in intact islets from ob/ob-mice by integrating flame photometry and the free ion in individual beta-cells by dual wavelength fluorometry. Whereas increasing the glucose concentration from 3 to 20 mM resulted in a lowering of sodium, the addition of 100 microM tolbutamide caused a rise. The above-mentioned effects were most marked (about 50%) for the physiologically significant free sodium. The data indicate a more important role for Na+ in the regulation of insulin release than so far acknowledged. Increase of Na+ may contribute to the secretory response to hypoglycemic sulfonylureas by providing an additional rise of cytoplasmic Ca2+.
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- ref (subject category)
- art (subject category)
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