Sökning: id:"swepub:oai:DiVA.org:uu-333059" >
The association bet...
The association between individual metabolic syndrome components, primary liver cancer and cirrhosis : A study in the Swedish AMORIS cohort
-
- Nderitu, Paul (författare)
- Guys & St Thomas NHS Fdn Trust, Dept Oncol, London SE1 9RT, England.
-
- Bosco, Cecilia (författare)
- Kings Coll London, Div Canc Studies, TOUR, London, England.
-
- Garmo, Hans (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kings Coll London, Div Canc Studies, TOUR, London, England.;Akad Sjukhuset, Reg Canc Ctr, Uppsala, Sweden.
-
visa fler...
-
- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Kings Coll London, Div Canc Studies, TOUR, London, England
-
- Malmström, Hakan (författare)
- Karolinska Institutet
-
- Hammar, Niklas (författare)
- Karolinska Institutet
-
- Walldius, Göran (författare)
- Karolinska Institutet
-
- Jungner, Ingmar (författare)
- Karolinska Inst, Dept Clin Epidemiol, Stockholm, Sweden.;CALAB Res, Stockholm, Sweden.
-
- Ross, Paul (författare)
- Guys & St Thomas NHS Fdn Trust, Dept Oncol, London SE1 9RT, England.
-
- Van Hemelrijck, Mieke (författare)
- Guys & St Thomas NHS Fdn Trust, Dept Oncol, London SE1 9RT, England.;Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
-
visa färre...
-
Guys & St Thomas NHS Fdn Trust, Dept Oncol, London SE1 9RT, England Kings Coll London, Div Canc Studies, TOUR, London, England. (creator_code:org_t)
- 2017-06-21
- 2017
- Engelska.
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 141:6, s. 1148-1160
- Relaterad länk:
-
https://onlinelibrar...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Metabolic syndrome (MetS) is associated with non-alcoholic fatty liver disease, which may progress to cirrhosis, a significant risk factor of hepatocellular carcinoma (HCC), the commonest malignant primary liver cancer (PLC). We investigated the association between the individual components of MetS (lipids, apolipoproteins, raised glucose, diabetes and obesity), PLC and cirrhosis. A total of 509,436 participants from the Swedish AMORIS cohort, recruited between January 1985 and December 1996 (end-date December 2011), aged >= 20 with baseline triglycerides (TG), total cholesterol (TC), glucose and liver enzymes were included. Those with baseline benign liver tumours, PLC or cirrhosis were excluded. Multivariate Cox regression, adjusted for age, gender, socio-economic status, liver disease (excluding cirrhosis) and MetS factors were used to estimate the association with PLC and cirrhosis. There were 766 PLC and 2,775 cirrhosis cases over 13 years. Raised TG, low TC, raised glucose, diabetes and low HDL were associated with an increased risk of developing PLC and cirrhosis. ApoB/ApoA-I ratio were also associated with PLC, whilst low LDL, raised TG/HDL, low ApoA-I and low ApoB were associated with cirrhosis. Obesity was significantly associated with PLC but not cirrhosis. Raised TG, low TC, raised glucose and diabetes showed stronger associations with PLC in participants with cirrhosis but many participants developed PLC without cirrhosis. Individual components of MetS (lipids, apolipoproteins, raised glucose, diabetes and obesity) were associated with an increased risk of developing PLC or cirrhosis. MetS components were more strongly associated with PLC with preceding cirrhosis history but many participants developed PLC without cirrhosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Primary liver cancer
- metabolic syndrome
- obesity
- lipids
- apolipoproteins
- diabetes
- hyperglycaemia
- cirrhosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nderitu, Paul
-
Bosco, Cecilia
-
Garmo, Hans
-
Holmberg, Lars
-
Malmström, Hakan
-
Hammar, Niklas
-
visa fler...
-
Walldius, Göran
-
Jungner, Ingmar
-
Ross, Paul
-
Van Hemelrijck, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet