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Silk fibroin hydrog...
Silk fibroin hydrogels induced and reinforced by acidic calcium phosphate : A simple way of producing bioactive and drug-loadable composites for biomedical applications
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Dong, Zhiyun (författare)
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- Wu, Dan, 1990- (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Engqvist, Håkan, 1972- (författare)
- Uppsala universitet,Tillämpad materialvetenskap,Materials in Medicine Group
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- Luo, Jun (författare)
- Uppsala universitet,Tillämpad materialvetenskap,Sichuan University
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- Persson, Cecilia (författare)
- Uppsala universitet,Tillämpad materialvetenskap,Medicinsk teknik
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: International Journal of Biological Macromolecules. - : Elsevier. - 0141-8130 .- 1879-0003. ; 193, s. 433-440
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Silk fibroin (SF) hydrogels have attracted extensive interest in biomedical applications due to their biocompatibility and wide availability. However, their generally poor mechanical properties limit their utility. Here, injectable, ready-to-use SF-based composites, simultaneously induced and reinforced by acidic calcium phosphates, were prepared via a dual-paste system requiring no complex chemical/physical treatment. The composite was formed by mixing a monocalcium phosphate monohydrate paste with a β-tricalcium phosphate/SF paste. The conformational transition of SF in an acidic environment forms continuous networks, and the acidic calcium phosphate, brushite and monetite, formed simultaneously in the networks during mixing. The composites displayed a partly elastomeric compression behavior, with mechanical properties increasing with an increasing calcium phosphate and β-sheet content at the lower calcium phosphate contents evaluated (22.2–36.4 wt%). While the stiffness was still relatively low, the materials presented a high elasticity and ductility, and no failure at stresses in the range of failure stresses of trabecular bone. Furthermore, the calcium phosphate confers bioactivity to the material, and the composites with a promising in vitro cell response also showed potential as drug vehicles, using vancomycin as a model drug. These dual-paste systems exhibit potential utility in biomedical applications, such as bone void fillers and drug vehicles.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Keramteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Ceramics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Kompositmaterial och -teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Composite Science and Engineering (hsv//eng)
Nyckelord
- silk fibroin
- acidic calcium phosphates
- composites
- hydrogels
- mechanical strength
- drug-loadable
- brushite
- dual-paste system
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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