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Inverse correlation...
Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures
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- Kuppe, Christoph (författare)
- Rhein Westfal TH Aachen, Div Nephrol & Immunol, Aachen, Germany
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- Rohlfs, Wilko (författare)
- Rhein Westfal TH Aachen, Inst Heat & Mass Transfer, Aachen, Germany
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- Grepl, Martin (författare)
- Rhein Westfal TH Aachen, Fac Math Informat & Nat Sci, Numer Math, Aachen, Germany
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- Schulte, Kevin (författare)
- Rhein Westfal TH Aachen, Div Nephrol & Immunol, Aachen, Germany;Univ Kiel, Dept Nephrol, Kiel, Germany
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- Veron, Delma (författare)
- Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA
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- Elger, Marlies (författare)
- Heidelberg Univ, Med Fac Mannheim, Dept Anat & Dev Biol, Mannheim, Germany
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- Sanden, Silja Kerstin (författare)
- Rhein Westfal TH Aachen, Div Nephrol & Immunol, Aachen, Germany
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- Saritas, Turgay (författare)
- Rhein Westfal TH Aachen, Div Nephrol & Immunol, Aachen, Germany
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- Andrae, Johanna (författare)
- Uppsala universitet,Vaskulärbiologi
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- Betsholtz, Christer (författare)
- Karolinska Institutet,Uppsala universitet,Vaskulärbiologi
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- Trautwein, Christian (författare)
- RWTH Aachen Univ Hosp, Div Gastroenterol & Endocrinol, Aachen, Germany
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- Hausmann, Ralf (författare)
- RWTH Aachen Univ Hosp, Inst Mol Pharmacol, Aachen, Germany
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- Quaggin, Susan (författare)
- Northwestern Univ, Div Med Nephrol, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA
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- Bachmann, Sebastian (författare)
- Charite, Dept Anat, Berlin, Germany
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- Kriz, Wilhelm (författare)
- Heidelberg Univ, Med Fac Mannheim, Dept Anat & Dev Biol, Mannheim, Germany
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- Tufro, Alda (författare)
- Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA
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- Floege, Jürgen (författare)
- Rhein Westfal TH Aachen, Div Nephrol & Immunol, Aachen, Germany
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- Moeller, Marcus J. (författare)
- Rhein Westfal TH Aachen, Div Nephrol & Immunol, Aachen, Germany;RWTH Aachen Univ Hosp, Interdisciplinary Ctr Clin Res IZKF Aachen, Aachen, Germany;Rhein Westfal TH Aachen, Heisenberg Chair Prevent & Translat Nephrol, Div Nephrol, Aachen, Germany
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(creator_code:org_t)
- 2018-04-09
- 2018
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : OXFORD UNIV PRESS. - 0931-0509 .- 1460-2385. ; 33:9, s. 1514-1525
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Vascular endothelial growth factor A (VEGF) is an essential growth factor during glomerular development and postnatal homeostasis. VEGF is secreted in high amounts by podocytes into the primary urine, back-filtered across the glomerular capillary wall to act on endothelial cells. So far it has been assumed that VEGF back-filtration is driven at a constant rate exclusively by diffusion.Methods: In the present work, glomerular VEGF back-filtration was investigated in vivo using a novel extended model based on endothelial fenestrations as surrogate marker for local VEGF concentrations. Single nephron glomerular filtration rate (SNGFR) and/or local filtration flux were manipulated by partial renal mass ablation, tubular ablation, and in transgenic mouse models of systemic or podocytic VEGF overexpression or reduction.Results: Our study shows positive correlations between VEGF back-filtration and SNGFR as well as effective filtration rate under physiological conditions along individual glomerular capillaries in rodents and humans.Conclusion: Our results suggest that an additional force drives VEGF back-filtration, potentially regulated by SNGFR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- endothelium
- filtration
- GFR
- glomerular hypertrophy
- VEGF
- streaming potential
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kuppe, Christoph
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Rohlfs, Wilko
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Grepl, Martin
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Schulte, Kevin
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Veron, Delma
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Elger, Marlies
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visa fler...
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Sanden, Silja Ke ...
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Saritas, Turgay
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Andrae, Johanna
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Betsholtz, Chris ...
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Trautwein, Chris ...
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Hausmann, Ralf
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Quaggin, Susan
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Bachmann, Sebast ...
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Kriz, Wilhelm
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Tufro, Alda
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Floege, Jürgen
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Moeller, Marcus ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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Nephrology, Dial ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet