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Convergent Evolutio...
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss
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- Lewis, William H (författare)
- Uppsala universitet,Molekylär evolution,Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England;Wageningen Univ, Dept Agrotechnol & Food Sci, Lab Microbiol, Wageningen, Netherlands
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- Lind, Anders E. (författare)
- Uppsala universitet,Molekylär evolution
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- Sendra, Kacper M. (författare)
- Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England
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- Onsbring Gustafson, Henning (författare)
- Uppsala universitet,Molekylär evolution,Wageningen Univ, Dept Agrotechnol & Food Sci, Lab Microbiol, Wageningen, Netherlands
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- Williams, Tom A. (författare)
- Univ Bristol, Sch Biol Sci, Bristol, Avon, England
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- Esteban, Genoveva F. (författare)
- Bournemouth Univ, Dept Life & Environm Sci, Poole, Dorset, England
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- Hirt, Robert P. (författare)
- Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England
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- Ettema, Thijs J. G. (författare)
- Uppsala universitet,Molekylär evolution,Wageningen Univ, Dept Agrotechnol & Food Sci, Lab Microbiol, Wageningen, Netherlands
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- Embley, T. Martin (författare)
- Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England
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(creator_code:org_t)
- 2019-10-24
- 2020
- Engelska.
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Ingår i: Molecular biology and evolution. - : OXFORD UNIV PRESS. - 0737-4038 .- 1537-1719. ; 37:2, s. 524-539
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Abstract
Ämnesord
Stäng
- Hydrogenosomes are H-2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H-2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H-2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- evolution
- genomics
- hydrogenosomes
- mitochondria
- microbial eukaryotes
- anaerobic metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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