Sökning: id:"swepub:oai:DiVA.org:uu-4489" >
The Role of Fibrobl...
The Role of Fibroblast Growth Factor 23 in Phosphate Homeostasis
-
- Larsson, Tobias Erik Martin, 1976- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
Jonsson, Kenneth (preses)
-
Ljunggren, Östen (preses)
-
visa fler...
-
- Jan De Beur, Suzanne, M.D (opponent)
- Division of Endocrinology, Baltimore
-
visa färre...
-
(creator_code:org_t)
- ISBN 9155460135
- Uppsala : Acta Universitatis Upsaliensis, 2004
- Engelska 78 s.
-
Serie: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 0282-7476 ; 1367
- Relaterad länk:
-
https://uu.diva-port... (primary) (Raw object)
-
visa fler...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The regulation of serum phosphate (Pi) concentrations is a complex process and our current models are far from complete. Due to major advancements in biotechnology and the development of more powerful research tools, recent advances in the field of genetics has led to the identification of several candidates for the long sought-after phosphatonin(s), or Pi regulating hormones. One of these candidates is fibroblast growth factor 23 (FGF-23) and this thesis is based upon studies of the role of FGF-23 in Pi homeostasis. We demonstrate that FGF-23 is a secreted protein which is highly expressed in tumors giving rise to oncogenic hypophosphatemic osteomalacia (OOM). Furthermore, we have developed a two-site enzyme-linked immunosorbent assay for the detection of circulating FGF-23 and established that FGF-23 is present in the circulation of healthy individuals. Also, FGF-23 serum levels are elevated in patients with disturbances in Pi homeostasis such as OOM, X-linked hypophosphatemic rickets (XLH) and chronic kidney disease and are likely to play an important role in the pathogenesis of these disorders. A transgenic mouse model that express human FGF-23 under the control of the α1(I) collagen promoter exhibit similar clinical and biochemical characteristics as do patients with OOM, XLH and autosomal dominant hypophosphatemic rickets indicating that FGF-23 is an important determinant of Pi homeostasis, vitamin D metabolism and bone mineralization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Medicine
- Fibroblast Growth Factor 23
- FGF-23
- phosphate homeostasis
- vitamin D metabolism
- sodium/phosphate cotransporters
- autosomal dominant hypophosphatemic rickets
- ADHR
- X-linked hypophosphatemic rickets
- XLH
- oncogenic osteomalacia
- OOM
- PHEX
- Medicin
- Dermatology and venerology,clinical genetics, internal medicine
- Dermatologi och venerologi, klinisk genetik, invärtesmedicin
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
Hitta via bibliotek
Till lärosätets databas