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Autologous haematop...
Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with 'aggressive' multiple sclerosis
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- Das, J. (författare)
- Royal Hallamshire Hosp, Sheffield Teaching Hosp NHS Fdn Trust, Acad Dept Neurol, Glossop Rd, Sheffield, S Yorkshire, England; Univ Sheffield, Sheffield Teaching Hosp NHS Fdn Trust, Sheffield Inst Translat Neurosci, UK Acad Dept Neurol, Sheffield, S Yorkshire, England
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- Snowden, J. A. (författare)
- Sheffield Teaching Hosp NHS Fdn Trust, Dept Haematol, Sheffield, S Yorkshire, England
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- Burman, Joachim, 1974- (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Freedman, M. S. (författare)
- Univ Ottawa, Dept Med Neurol, Ottawa, ON, Canada; Ottawa Hosp Res Inst, Ottawa, ON, Canada
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- Atkins, H. (författare)
- Univ Ottawa, Dept Med Neurol, Ottawa, ON, Canada; Ottawa Hosp Res Inst, Ottawa, ON, Canada
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- Bowman, M. (författare)
- Univ Ottawa, Dept Med Neurol, Ottawa, ON, Canada; Ottawa Hosp Res Inst, Ottawa, ON, Canada
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- Burt, R. K. (författare)
- Northwestern Univ, Feinberg Sch Med, Div Immunotherapy, Chicago, IL 60611 USA
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- Saccardi, R. (författare)
- Careggi Univ Hosp, Dept Cellular Therapies & Transfus Med, Florence, Italy
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- Innocenti, C. (författare)
- Careggi Univ Hosp, Dept Cellular Therapies & Transfus Med, Florence, Italy
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- Mistry, S. (författare)
- Sheffield Teaching Hosp NHS Fdn Trust, Acad Dept Neurol, Sheffield, S Yorkshire, England
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- Laud, P. J. (författare)
- Univ Sheffield, Stat Serv Unit, Sheffield, S Yorkshire, England
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- Jessop, H. (författare)
- Sheffield Teaching Hosp NHS Fdn Trust, Dept Haematol, Sheffield, S Yorkshire, England
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- Sharrack, B. (författare)
- Sheffield Teaching Hosp NHS Fdn Trust, Acad Dept Neurol, Sheffield, S Yorkshire, England; Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England
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(creator_code:org_t)
- 2021-02-10
- 2021
- Engelska.
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Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 27:8, s. 1198-1204
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Abstract
Ämnesord
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- Background:Autologous haematopoietic stem cell transplantation (AHSCT) is an effective treatment for patients with multiple sclerosis (MS) who have highly active disease, despite the use of standard disease-modifying therapies (DMTs). However, the optimal time for offering AHSCT to patients with ‘aggressive’ MS is yet to be established.Objectives:The objective was to explore the safety and efficacy of AHSCT as a first-line DMT in patients with ‘aggressive’ MS.Methods:All patients with ‘aggressive’ MS who received AHSCT as a first-line DMT in five European and North American centres were retrospectively evaluated.Results:Twenty patients were identified. The median interval between diagnosis and AHSCT was 5 (1–20) months. All had multiple poor prognostic markers with a median pre-transplant Expanded Disability Status Scale (EDSS) score of 5.0 (1.5–9.5). After a median follow-up of 30 (12–118) months, the median EDSS score improved to 2.0 (0–6.5, p < 0.0001). No patient had further relapses. Three had residual magnetic resonance imaging (MRI) disease activities in the first 6 months post-transplant, but no further new or enhancing lesions were observed in subsequent scans.Conclusion:AHSCT is safe and effective as a first-line DMT in inducing rapid and sustained remission in patients with ‘aggressive’ MS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Autologous haematopoietic stem cell transplantation
- multiple sclerosis
- aggressive multiple sclerosis
- disease-modifying therapy
- no evidence of disease activity
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- Av författaren/redakt...
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Das, J.
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Snowden, J. A.
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Burman, Joachim, ...
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Freedman, M. S.
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Atkins, H.
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Bowman, M.
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visa fler...
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Burt, R. K.
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Saccardi, R.
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Innocenti, C.
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Mistry, S.
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Laud, P. J.
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Jessop, H.
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Sharrack, B.
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Neurologi
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Uppsala universitet