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Cardiovascular outc...
Cardiovascular outcomes in transgender individuals in Sweden after initiation of gender-affirming hormone therapy
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- Karalexi, Maria (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Frisell, Thomas (författare)
- Karolinska Institutet
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- Cnattingius, Sven (författare)
- Karolinska Institutet
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- Holmberg, Dag (författare)
- Karolinska Institutet
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- Holmberg, Mats (författare)
- Karolinska Institutet
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- Kollia, Natasa (författare)
- Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17671, Greece.
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- Skalkidou, Alkistis, 1977- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Papadopoulos, Fotios C. (författare)
- Uppsala Univ Hosp, Dept Med Sci, Psychiat, S-75185 Uppsala, Sweden.
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(creator_code:org_t)
- 2022-07-02
- 2022
- Engelska.
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press. - 2047-4873 .- 2047-4881. ; 29:15, s. 2017-2026
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- Aims We compared the incidence of cardiovascular disease (CVD) in transgender participants with a diagnosis of gender dysphoria (GD) with and without gender-affirming hormone therapy (GAHT) to the incidence observed in the general population. Methods and results The population-based cohort included all individuals >10 years in Sweden linked to Swedish nationwide healthcare Registers (2006-16). Two comparator groups without GD/GAHT were matched (1:10) on age, county of residence, and on male and female birth-assigned sex, respectively. Cox proportional models provided hazard ratios (HRs) and 95% confidence intervals (CI) for CVD outcomes. Among 1779 transgender individuals [48% birth-assigned males (AMAB), 52% birth-assigned females (AFAB)], 18 developed CVD, most of which were conduction disorders. The incidence of CVD for AFAB individuals with GD was 3.7 per 1000 person-years (95% CI: 1.4-10.0). Assigned male at birth individuals with GD had an incidence of CVD event of 7.1 per 1000 person-years (95% CI: 4.2-12.0). The risk of CVD event was 2.4 times higher in AMAB individuals (HR: 2.4, 95% CI: 1.3-4.2) compared with cisgender women, and 1.7 higher compared with cisgender men (HR: 1.7, 95% CI: 1.0-2.9). Analysis limited to transgender individuals without GAHT yielded similar results to those with GAHT treatment. Conclusion The incidence of CVD among GD/GAHT individuals was low, although increased compared with matched individuals without GD and similar to the incidence among GD/no GAHT individuals, thus not lending support for a causal relationship between treatment and CVD outcomes. Larger studies with longer follow-up are needed to verify these findings, as well as possible effect modification by comorbidity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Transgender
- Gender dysphoria
- Gender-affirming hormone therapy
- Cardiovascular disease
- Conduction disorders
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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