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Broad spectrum of t...
Broad spectrum of time of detection, primary symptoms and disease progression in infants with HIV-1 infection
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- Naver, Lars (författare)
- Karolinska Institutet
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- Ehrnst, A. (författare)
- Karolinska Institutet
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Belfrage, E. (författare)
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Blomberg, J. (författare)
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- Christensson, Bertil (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Forsgren, M. (författare)
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Lidin-Janson, G. (författare)
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Lindgren, S. (författare)
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- Ljung, Rolf (författare)
- Lund University,Lunds universitet,Enheten för pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatric Hematologic Research Group,Lund University Research Groups
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- Sönnerborg, A (författare)
- Karolinska Institutet
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- Bohlin, A. B. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2001
- 2001
- Engelska.
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Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 20:3, s. 159-166
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The relationship between time of HIV-1 detection, appearance of symptoms and disease progression was studied in all 24 HIV-1-infected infants from a cohort of 117 children who were born to HIV-1-infected mothers and monitored from birth. HIV isolation from plasma and mononuclear cells, HIV-1 DNA PCR (polymerase chain reaction) and, retrospectively, a quantitative assay for HIV-1 RNA were used for virus detection. Two infants possibly exhibited a symptomatic primary HIV infection. More children with than without symptoms during the first year of life progressed to immunological class 3 (P=0.013) and to AIDS or death (P=0.003) during follow-up. HIV-1 was detected within 4 days of age in 4 of 16 infants: 3 of them became symptomatic within 1 year, as did 6 of the remaining 12 infants (not statistically significant). All four infants in whom virus was detected within 4 days of age progressed to severe immunosuppression, compared to 6 of 14 in whom the virus detection test was initially negative prior to the first positive result (n.s.). Two children with previous repeatedly negative HIV detection tests were diagnosed with HIV-1 infection at 8 and 9 months, respectively. Repeated blood sampling is needed for the diagnosis of HIV-1 infection in perinatally exposed infants, and virus detection tests for exclusion of HIV-1 infection must be used with caution.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Naver, Lars
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Ehrnst, A.
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Belfrage, E.
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Blomberg, J.
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Christensson, Be ...
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Forsgren, M.
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visa fler...
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Lidin-Janson, G.
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Lindgren, S.
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Ljung, Rolf
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Sönnerborg, A
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Bohlin, A. B.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet