Shutdown in protein synthesis due to the expression of mini-genes in bacteria

• Mutants of Escherichia coli partially deficient in peptidyl-tRNA hydrolase are killed by the expression of certain very short open reading frames (mini-genes), encoded by the wild-type bar regions of phage lambda. According to the current hypothesis, prot

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peptidyl-tRNA hydrolase; mini-gene; translation termination; ribosome recycling; Shine-Dalgarno interaction; PEPTIDYL-TRANSFER-RNA; ESCHERICHIA-COLI RIBOSOMES; RELEASE FACTOR RF3; LACZ MESSENGER-RNA; GROWTH-INHIBITION; AMINO-ACID; TRANSLATION; EFFICIENCY

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