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Short Article Hypot...
Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity
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Castellanos-Jankiewicz, A. (author)
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Guzman-Quevedo, O. (author)
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Fenelon, V. S. (author)
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Zizzari, P. (author)
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Quarta, C. (author)
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Bellocchio, L. (author)
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Tailleux, A. (author)
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Charton, J. (author)
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Fernandois, D. (author)
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- Henricsson, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Piveteau, C. (author)
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Simon, V. (author)
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Allard, C. (author)
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Quemener, S. (author)
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Guinot, V. (author)
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Hennuyer, N. (author)
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Perino, A. (author)
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Duveau, A. (author)
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Maitre, M. (author)
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Leste-Lasserre, T. (author)
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Clark, S. (author)
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Dupuy, N. (author)
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Cannich, A. (author)
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Gonzales, D. (author)
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Deprez, B. (author)
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Mithieux, G. (author)
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Dombrowicz, D. (author)
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Prevot, V. (author)
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Marsicano, G. (author)
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Staels, B. (author)
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Schoonjans, K. (author)
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Cota, D. (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 33:7
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https://doi.org/10.1...
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Abstract
Subject headings
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- Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet induced obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Castellanos-Jank ...
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Guzman-Quevedo, ...
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Fenelon, V. S.
-
Zizzari, P.
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Quarta, C.
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Bellocchio, L.
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show more...
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Tailleux, A.
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Charton, J.
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Fernandois, D.
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Henricsson, Marc ...
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Piveteau, C.
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Simon, V.
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Allard, C.
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Quemener, S.
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Guinot, V.
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Hennuyer, N.
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Perino, A.
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Duveau, A.
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Maitre, M.
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Leste-Lasserre, ...
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Clark, S.
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Dupuy, N.
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Cannich, A.
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Gonzales, D.
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Deprez, B.
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Mithieux, G.
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Dombrowicz, D.
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Bäckhed, Fredrik ...
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Prevot, V.
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Marsicano, G.
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Staels, B.
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Schoonjans, K.
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Cota, D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Cell Metabolism
- By the university
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University of Gothenburg