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Left-Sided Degenera...
Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2 Diabetes
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- Rawshani, Araz, 1986 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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Sattar, N. (författare)
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McGuire, D. K. (författare)
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- Wallström, Oskar (författare)
- Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Smith, Ulf, 1943 (författare)
- Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Borén, Jan, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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- Bergström, Göran, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Omerovic, Elmir, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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- Rosengren, Annika, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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- Eliasson, Björn, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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Bhatt, D. L. (författare)
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- Rawshani, Aidin, 1991 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- Engelska.
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Ingår i: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 146:5, s. 398-411
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The role of diabetes in the development of valvular heart disease, and, in particular, the relation with risk factor control, has not been extensively studied. Methods: We included 715 143 patients with diabetes registered in the Swedish National Diabetes Register and compared them with 2 732 333 matched controls randomly selected from the general population. First, trends were analyzed with incidence rates and Cox regression, which was also used to assess diabetes as a risk factor compared with controls, and, second, separately in patients with diabetes according to the presence of 5 risk factors. Results: The incidence of valvular outcomes is increasing among patients with diabetes and the general population. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were associated with valvular lesions. Hazard ratios for patients with type 2 diabetes who had nearly all risk factors within target ranges, compared with controls, were as follows: aortic stenosis 1.34 (95% CI, 1.31-1.38), aortic regurgitation 0.67 (95% CI, 0.64-0.70), mitral stenosis 1.95 (95% CI, 1.76-2.20), and mitral regurgitation 0.82 (95% CI, 0.79-0.85). Hazard ratios for patients with type 1 diabetes and nearly optimal risk factor control were as follows: aortic stenosis 2.01 (95% CI, 1.58-2.56), aortic regurgitation 0.63 (95% CI, 0.43-0.94), and mitral stenosis 3.47 (95% CI, 1.37-8.84). Excess risk in patients with type 2 diabetes for stenotic lesions showed hazard ratios for aortic stenosis 1.62 (95% CI, 1.59-1.65), mitral stenosis 2.28 (95% CI, 2.08-2.50), and excess risk in patients with type 1 diabetes showed hazard ratios of 2.59 (95% CI, 2.21-3.05) and 11.43 (95% CI, 6.18-21.15), respectively. Risk for aortic and mitral regurgitation was lower in type 2 diabetes: 0.81 (95% CI, 0.78-0.84) and 0.95 (95% CI, 0.92-0.98), respectively. Conclusions: Individuals with type 1 and 2 diabetes have greater risk for stenotic lesions, whereas risk for valvular regurgitation was lower in patients with type 2 diabetes. Patients with well-controlled cardiovascular risk factors continued to display higher risk for valvular stenosis, without a clear stepwise decrease in risk between various degrees of risk factor control.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- aortic valve disease
- diabetes mellitus
- epidemiology
- mitral valve
- disease
- risk factors
- mitral annular calcification
- aortic-valve implantation
- risk-factors
- temporal trends
- stenosis
- transcatheter
- association
- mortality
- progression
- prevalence
- Cardiovascular System & Cardiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Rawshani, Araz, ...
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Sattar, N.
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McGuire, D. K.
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Wallström, Oskar
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Smith, Ulf, 1943
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Borén, Jan, 1963
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visa fler...
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Bergström, Göran ...
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Omerovic, Elmir, ...
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Rosengren, Annik ...
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Eliasson, Björn, ...
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Bhatt, D. L.
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Rawshani, Aidin, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Göteborgs universitet