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Off-pump CABG reduc...
Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study.
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Johansson-Synnergren, Mats, 1968 (author)
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- Nilsson, Folke, 1950 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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- Bengtsson, Anders, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Jeppsson, Anders, 1960 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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- Wiklund, Lars, 1954 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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(creator_code:org_t)
- 2009-07-12
- 2004
- English.
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In: Scandinavian cardiovascular journal : SCJ. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 38:1, s. 53-8
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Abstract
Subject headings
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- OBJECTIVE--Cardiac surgery initiates a systemic inflammatory response, which may affect endothelial function. The aim of this study was to investigate if off-pump CABG (OPCAB) reduces the postoperative inflammatory response and affects endothelial function less than conventional on-pump CABG. DESIGN--Fifty-two patients submitted for elective CABG were included in a prospective, randomized study. Twenty-six patients were operated with, and 26 without cardiopulmonary bypass (CPB). Plasma levels of complement (C3a), cytokines (IL-8, TNF-alpha), endothelin-1 and neopterin were measured before and during surgery and 2 and 24 h after surgery. Endothelial function was assessed by forearm plethysmography and acetylcholine infusion in 30 patients 2-4 h after surgery. RESULTS--C3a and neopterin concentrations were significantly higher during and early after surgery in the CPB group while TNF-alpha and IL-8 tended to be higher in the CPB group but the difference did not reach statistical significance. Endothelial function did not differ significantly between the two groups. CONCLUSION--OPCAB reduces complement activation compared with on-pump CABG but does not significantly affect TNF-alpha and IL-8 release or endothelial function.
Keyword
- Acetylcholine
- administration & dosage
- Area Under Curve
- Biological Markers
- blood
- Cardiopulmonary Bypass
- Complement Activation
- drug effects
- physiology
- Complement C3a
- drug effects
- metabolism
- Coronary Artery Bypass
- Dose-Response Relationship
- Drug
- Endothelin-1
- blood
- drug effects
- Endothelium
- Vascular
- metabolism
- physiopathology
- surgery
- Female
- Forearm
- blood supply
- Humans
- Interleukin-8
- blood
- Male
- Middle Aged
- Neopterin
- blood
- Nitroprusside
- administration & dosage
- Prospective Studies
- Regional Blood Flow
- drug effects
- physiology
- Treatment Outcome
- Tumor Necrosis Factor-alpha
- drug effects
- metabolism
- Vasodilation
- drug effects
- physiology
- Vasodilator Agents
- administration & dosage
Publication and Content Type
- ref (subject category)
- art (subject category)
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